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Title Prevention of coronary heart disease : from the cholesterol hypothesis to [omega]6/ [omega]3 balance / volume editor, Harumi Okuyama ; authors, Harumi Okuyama [and others]
Published Basel ; New York : Karger, ©2007


Description 1 online resource (x, 168 pages) : illustrations (chiefly color)
Series World review of nutrition and dietetics, 0084-2230 ; v. 96
World review of nutrition and dietetics ; v. 96. 0084-2230
Contents The cholesterol hypothesis--its basis and its faults -- Association of high total cholesterol with coronary heart disease mortality differs among subject populations--Familial hypercholesterolemia as a key concept -- Cancer and all-cause mortalities are lower in the higher total cholesterol groups among general populations -- Pleiotropic effects of statins in the prevention of coronary heart disease--potential side effects -- Objective measures of pathology of coronary heart disease -- [omega]3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome -- Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? -- Mechanisms by which dietary fats affect coronary heart disease mortality -- Cancers common in the USA are stimulated by [omega]6 fatty acids and large amounts of animal fats, but suppressed by [omega]3 fatty acids and cholesterol -- New directions of lipid nutrition for the primary and secondary prevention of coronary heart disease and other late-onset diseases
Summary This publication is organized in an exceptional way: Each chapter introduces several completed clinical trials and provides the original conclusions and discussions of the results. The authors then contribute their own comments and interpretations of the findings, challenging the prevailing belief that serum cholesterol is a mediator of disease which is increased by eating saturated fats and decreased by eating polyunsaturated fats. They argue that upon closer scrutiny, the diet recommendations based on the cholesterol hypothesis are essentially ineffective in reducing serum cholesterol levels in the long run. Instead, it is proposed that traditional cholesterol biomarkers are of different significance in short- and long-term interventions due to the feedback control mechanisms in the body. Even more important, the association of high serum cholesterol values with high coronary heart disease mortality is not consistent when different populations are compared: This mortality rate may simply reflect the incidence and severity of familial hypercholesterolemia cases. This agrees with the observation that higher serum cholesterol values associate with lower cancer and all-cause mortalities in populations with a low relative proportion of this disorder. Thus, there seems to be no benefit of limiting dietary cholesterol intake or lowering serum cholesterol values below a certain limit. Moreover, evidence has been found that the health risk results from high intakes of calories, aggravated by an unbalanced intake of omega6/omega3 polyunsaturated fats. Based on the reviewed data, new directions of lipid nutrition are recommended for the primary and secondary prevention of coronary heart disease, cancer and all-cause deaths, which will likely revolutionize current dietary practice
Bibliography Includes bibliographical references (pages 159-165) and index
Notes Print version record
Subject Coronary heart disease -- Prevention
Coronary heart disease -- Nutritional aspects.
Omega-6/omega-3 fatty acid ratio.
Coronary heart disease.
Coronary Disease
Coronary Disease -- prevention & control
Fatty Acids
HEALTH & FITNESS -- Diseases -- Heart.
MEDICAL -- Cardiology.
Coronary heart disease
Coronary heart disease -- Nutritional aspects
Coronary heart disease -- Prevention
Omega-6/omega-3 fatty acid ratio
Coronariopatia (prevenção e controle)
Ácidos graxos omega 3.
Ácidos graxos omega 6.
Ácidos graxos.
Koronare Herzkrankheit -- Prävention.
Form Electronic book
Author Okuyama, Harumi.
ISBN 9783318013986