Hewley, Sarah, 1627-1710. : Lady Hewley's charities : a full report of the hearing in the House of Lords on the 13th, 14th, and 15th day of May, and the 24th, 25th, and 28th of June, 1839 : on the appeal of the trustees : (from the short-hand notes of Messrs. Gurney and son) : to which are prefixed, the judgment of the vice-chancellor, on the original hearing of the cause before him, Dec. 23rd, 1833, the judgment of Lord Lyndhurst on the appeal to him as Lord Chancellor, delivered 5th Feb., 1836 : the case of the appellants : the case of the respondents
1839
1
Hewley, Sarah, 1627-1710 -- Will : Substance of the speech of Charles Purton Cooper, Esq. : as counsel for the Rev. Charles Wellbeloved, in the suit of the Attorney General versus Shore : instituted in the High Court of Chancery, respecting Lady Hewley's foundations, Wednesday, 2d July, 1834
A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits. Deficiency of hexosaminidase A due to mutations in the gene encoding the hexosaminidase alpha subunit is a case of TAY-SACHS DISEASE. Deficiency of hexosaminidase A and HEXOSAMINIDASE B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE
An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry
