| Description |
1 online resource (xi, 96 pages) : illustrations |
| Contents |
Introduction and Background Biology / Angelica Fasolo, Stefania Zambelli, Luca Gianni -- HER2 Testing / Mary Falzon, Michael Gandy -- HER2-Positive Breast Cancer: Adjuvant and Neoadjuvant Therapy / Nadia Harbeck -- HER2-Positive Metastatic Breast Cancer: First-Line Treatment / Leticia De Mattos-Arruda, Javier Cortés -- HER2-Positive Metastatic Breast Cancer: Second-Line Treatment / Ricardo H. Alvarez -- Emerging Targeted Agents for HER2-Positive Breast Cancer / Dimitrios Zardavas, Martine Piccart |
| Summary |
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15-25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings |
| Analysis |
therapie |
|
therapy |
|
farmacologie |
|
pharmacology |
|
eerstelijnsgezondheidszorg |
|
primary health care |
|
geneeskunde |
|
medicine |
|
volksgezondheid |
|
public health |
|
oncologie |
|
oncology |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed June 5, 2014) |
| Subject |
Breast -- Cancer -- Chemotherapy -- Handbooks, manuals, etc
|
|
HER-2 gene -- Handbooks, manuals, etc
|
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Breast Neoplasms -- drug therapy
|
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Breast -- Cancer -- Chemotherapy
|
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HER-2 gene
|
| Genre/Form |
handbooks.
|
|
Handbooks and manuals
|
|
Handbooks and manuals.
|
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Guides et manuels.
|
| Form |
Electronic book
|
| Author |
Alvarez, Ricardo H., author
|
| ISBN |
9781907673948 |
|
1907673946 |
|
