Limit search to available items
Book Cover

Title Notch regulation of the immune system / Freddy Radtke, editor
Published Berlin ; New York : Springer, ©2012


Description 1 online resource
Series Current topics in microbiology and immunology, 0070-217X ; v. 360
Current topics in microbiology and immunology ; v. 360.
Contents The Notch Pathway in Hematopoietic Stem Cells / Anna Bigas, Teresa D'Altri and Lluis Espinosa -- Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanism / Divya K. Shah and Juan Carlos Zúñiga-Pflücker -- Notch1 and IL-7 Receptor Signalling in Early T-cell Development and Leukaemia / Sara González-García, Marina García-Peydró, Juan Alcain and María L. Toribio -- Notch Signaling During Human T cell Development / Tom Taghon, Els Waegemans and Inge Van de Walle -- Canonical and Non-Canonical Notch Signaling in CD4+ T Cells / Lisa M. Minter and Barbara A. Osborne -- The Role of Notch in the Differentiation of CD4+ T Helper Cells / Floriane Auderset, Manuel Coutaz and Fabienne Tacchini-Cottier -- Notch Signaling in Alloreactive T Cell Immunity / Jooho Chung and Ivan Maillard -- Notch2 and Immune Function / Mamiko Sakata-Yanagimoto and Shigeru Chiba -- Recent Advances on NOTCH Signaling in T-ALL / Gannie Tzoneva and Adolfo A. Ferrando
Summary Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This volume of Current Topics in Microbiology and Immunology covers divers topics of Notch function within the immune system.¡ The review series starts with an overview on the role of Notch function for the generation, and specification of hematopoietic stem cells during mouse development and adulthood. Chapters follow describing molecular players and specific functions of Notch during T cell lineage commitment and maturation in both mouse and human. Once T cell development is accomplished and T cells have been positively and negatively selected, they migrate from the thymus to the periphery. There they regulate host defense to pathogens as well as immune homeostasis, which is described in two chapters of this series. A subsequent report summarizes recent findings suggesting a role of Notch in regulating alloreactive T cell immunity. This process mediates recognition of foreign antigens in recipients of organ transplants. The family of Notch receptors consists of four family members (Notch1-4). Some aspects of Notch function in immunity are regulated by single others by multiple receptors. One review of this series describes the specific function of Notch2 during hematopoietic lineage specification and immune function. The last chapter is dedicated to the oncogenic properties of NOTCH1 in T cell acute lymphoblastic leukemia (T-ALL) and potential avenues of targeting NOTCH1 therapeutically. Collectively these reviews summarize the pleiotropic functions of Notch in immunity and there is undoubtedly more to come in the future
Analysis Medicine
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Subject Immune response -- Regulation.
Notch genes.
Transcription factors.
Cell receptors.
Membrane proteins.
Hematopoietic system.
Notch proteins.
Receptors, Notch -- immunology
Transcription Factors
Hemic and Immune Systems
Receptors, Cell Surface
Membrane Proteins
Amino Acids, Peptides, and Proteins
Chemicals and Drugs
Hematopoietic System
Receptors, Notch
Hematopoietic System -- immunology
SCIENCE -- Life Sciences -- Anatomy & Physiology.
Transcription factors
Notch proteins
Membrane proteins
Hematopoietic system
Cell receptors
Immune response -- Regulation
Notch genes
Form Electronic book
Author Radtke, Freddy
LC no. 2012943368
ISBN 9783642242946