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Title Pulmonary and critical care considerations of hematopoietic stem cell transplantation / Ayman O. Soubani, editor
Published Cham : Springer, [2023]


Description 1 online resource (xxii, 493 pages) : illustrations (some color)
Contents Intro -- Foreword I -- Foreword II -- Preface -- Contents -- Editor and Contributors -- About the Editor -- Contributors -- 1: Hematopoietic Stem Cell Transplantation: An Overview -- Introduction -- Autologous Stem Cell Transplant -- Collection of Stem Cells -- Risk Factors of Poor Mobilization -- Conditioning Regimen -- Allogeneic Stem Cell Transplant -- Donor Selection for Allogeneic HSCT -- Sources of Hematopoietic Stem Cells -- Bone Marrow -- Peripheral Blood -- Umbilical Cord Blood (UCB) -- Conditioning Regimen -- Complications of Stem Cell Transplantation -- Early Complications
Graft-Versus-Host Disease (GVHD) -- Infectious Diseases -- Pre-engraftment: From HSCT to Engraftment (Day 0 to +30) -- Early Post-engraftment: Day +30-100 -- Late Post-engraftment: Beyond Day +100 -- Oral Mucositis -- Hemorrhagic Cystitis -- Sinusoidal Obstruction Syndrome (SOS) -- Transplant-Associated Microangiopathy (TMA) -- Late Complications -- References -- 2: An Overview of Graft-Versus-Host Disease -- Introduction -- Pathophysiology of GVHD -- GVHD: Incidence and Impact on Non-relapse Mortality (NRM) -- Risk Factors of GVHD -- Classification of GVHD -- Staging and Grading of Acute GVHD
Staging/Grading of Chronic GVHD -- Introduction of the Concept of GVHD Prophylaxis -- Introduction of Cyclosporine A for GVHD Prophylaxis -- Use of Combination Drugs for GVHD Prophylaxis -- Trials Assessing Tacrolimus Versus CsA -- Mycophenolate Mofetil (MMF) -- Antithymocyte Globulin (ATG) for In Vivo T-Cell Depletion -- Posttransplantation Cyclophosphamide (PTCy) -- Sirolimus -- Ex Vivo T-Cell Depletion for GVHD Prophylaxis -- Targeting T-Cell Co-stimulatory Receptors -- Treatment of GVHD -- Pulmonary Perspectives -- References
3: Pulmonary Complications Following Hematopoietic Stem Cell Transplantation: Spectrum, Incidence, Risk Factors, and Outcomes -- Introduction -- Infectious Complications -- Bacterial Complications -- Pneumonia -- Nocardia -- Mycobacterium tuberculosis (MTB) -- Nontuberculous Mycobacterial Infections -- Viral Complications -- Cytomegalovirus -- Respiratory Virus Infections (RVI) -- SARS-CoV-2 -- Invasive Fungal Infections -- Noninfectious Complications -- Idiopathic Pneumonia Syndrome (IPS) -- Peri-Engraftment Respiratory Distress Syndrome (PERDS) -- Diffuse Alveolar Hemorrhage (DAH)
Cryptogenic Organizing Pneumonia (COP) -- Bronchiolitis Obliterans Syndrome (BOS) -- Interstitial Lung Disease (ILD) -- Pulmonary Hypertension and Pulmonary Veno-Occlusive Disease (PVOD) -- Thoracic Air Leak Syndrome (TALS) -- Pleural Effusions -- Venous Thromboembolic Disease (VTE) and Pulmonary Cytolytic Thrombi (PCT) -- Other Noninfectious Complications -- Acute Respiratory Failure and Mechanical Ventilation -- Diagnostic Considerations of Noninfectious Pulmonary Complications Following HSCT -- Conclusion -- References -- 4: Pretransplant Pulmonary Evaluation -- Introduction
Summary This book serves as a guide to the pulmonary and critical care complications of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population. The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation. This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed June 26, 2023)
Subject Hematopoietic stem cells -- Transplantation
Hematopoietic stem cell disorders -- Treatment
Critical care medicine.
Lungs -- Diseases.
Critical Care
Lung Diseases
Critical care medicine
Hematopoietic stem cells -- Transplantation
Lungs -- Diseases
Form Electronic book
Author Soubani, Ayman O., editor.
ISBN 9783031287978