Title Diagnostic pathology of hematopoietic disorders of spleen and liver / Ling Zhang, Haipeng Shao, Serhan Alkan, editors

Published Cham : Springer, 2020

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Description 1 online resource Contents Intro -- Preface -- Contents -- Contributors -- 1: Anatomy and Histology of Normal Liver and Spleen -- Spleen -- Anatomy -- Embryology -- Normal Function -- Imaging Findings -- Gross -- Microscopic Findings -- White Pulp -- Red Pulp -- Liver -- Anatomy -- Embryology -- Normal Function -- Imaging Findings -- Gross -- Microscopic Findings -- References -- 2: Diagnostic Approaches to Hematopoietic Disorders of the Spleen and Liver -- Introduction -- Spleen -- Indications of Splenectomy -- Indications of Splenic Fine Needle Aspirate and Needle Core Biopsy -- Grossing -- Spleen from Splenectomy Splenic Biopsy -- Laparoscopic Splenectomy -- Sample Processing -- Microscopy -- Ancillary Studies -- Immunohistochemistry Study -- Flow Cytometry -- Liver -- Indications for Liver Biopsy -- Imaging Study -- Grossing -- Liver Biopsy -- Resection/Lobectomy -- Sample Processing -- Fixation, Routine, and Special Staining -- Microscopic Examination -- Ancillary Studies -- Flow Cytometry -- Immunohistochemistry Study -- References -- 3: Molecular and Genetic Diagnostic Approaches of Hematopoietic Disorders of the Spleen and Liver -- Introduction -- Cytogenetics -- Conventional Karyotyping Fluorescence In Situ Hybridization (FISH) -- Cytogenetic Abnormalities Detectable by Conventional Karyotyping or FISH in Lymphomas -- Array-Based Comparative Genomic Hybridization (aCGH) and Single-Nucleotide Polymorphism (SNP) Array -- Polymerase Chain Reaction -- B- and T-Cell Receptor Studies -- Sanger Sequencing -- Next-Generation Sequencing -- Genetic Mutations in Splenic and Hepatic Lymphomas -- References -- 4: Hairy Cell Leukemia, Hairy Cell Leukemia Variant, and Splenic Diffuse Red Pulp Small B-Cell Lymphoma -- Introduction -- Hairy Cell Leukemia -- Definition -- Cell Origin Epidemiology -- Etiology and Pathogenesis -- Clinical Presentations -- Morphology -- Gross Features -- Microscopic Features -- Peripheral Blood -- Bone Marrow -- Spleen, Liver, and Lymph Nodes -- Cytochemical Findings and Immunophenotyping -- Cytogenetics -- Molecular Findings -- Differential Diagnosis -- Hairy Cell Leukemia Variant (HCL-V) -- Splenic Marginal Zone Lymphoma (SMZL) -- Mantle Cell Lymphoma -- Chronic Lymphocytic Leukemia (CLL) -- Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL) -- Aplastic Anemia -- Prognosis and Treatment -- Diagnostic Caveats Splenic B-Cell Lymphoma/Leukemia, Unclassifiable -- Hairy Cell Leukemia, Variant -- Etiology and Pathogenesis -- Epidemiology -- Clinical Presentations -- Morphology -- Cytochemical Findings and Immunophenotyping -- Cytogenetics and Molecular Findings -- Differential Diagnosis -- Hairy Cell Leukemia (HCL) -- Splenic Marginal Zone Lymphoma (SMZL) -- Splenic Diffuse Red Pulp Small B-cell Lymphoma (SDRPL) -- Treatment -- Splenic Diffuse Red Pulp Small B-Cell Lymphoma (SDRPL) -- Etiology and Pathogenesis -- Epidemiology -- Clinical Presentations -- Morphology Summary This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists Subject Hematopoietic system -- Diseases Hematopoietic system. Leukemia. Lymphomas. Liver -- Diseases. Spleen. Hematopoietic System Leukemia Lymphoma Neoplasms, Plasma Cell Liver Diseases Spleen Haematology. Oncology. Pathology. Medical -- Hematology. Medical -- Oncology. Medical -- Pathology. Spleen Lymphomas Liver -- Diseases Leukemia Hematopoietic system Hematopoietic system -- Diseases Malalties hematològiques. Malalties del sistema limfàtic. Melsa. Fetge. Diagnòstic. Oncologia. Genre/Form Electronic books Llibres electrònics. Form Electronic book Author Zhang, Ling Shao, Haipeng. Alkan, Serhan ISBN 9783030377083 3030377083 9783030377090 3030377091 9783030377106 3030377105

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