| Description |
1 online resource (xv, 622 pages) : illustrations |
| Contents |
TRANSCRIPTION FACTORS; CONTENTS; Introduction; Contributors; I TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES; II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE; III TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE; IV. TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION; V. ONCOGENESIS AND HEMATOPOIESIS; VI. SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES; Index |
| Summary |
The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Blood cells.
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Hematopoiesis -- Regulations.
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Leukemia.
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Transcription factors.
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Gene Expression Regulation.
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Hematopoiesis -- physiology.
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Leukemia -- genetics.
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Transcription Factors -- physiology.
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Transcription, Genetic.
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| Genre/Form |
Rules.
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Administrative regulations.
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| Form |
Electronic book
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| Author |
Licht, Jonathan D.
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Ravid, Katya.
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| ISBN |
0471223883 (Electronic) |
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0471461067 (electronic bk.) |
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9780471223887 (Electronic) |
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9780471461067 (electronic bk.) |
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(cloth ; alk. paper) |
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