| Description |
1 online resource (x, 492 pages) : illustrations (some color) |
| Series |
Protein science and engineering |
|
Protein science and engineering.
|
| Contents |
SMALL STRESS PROTEINS AND HUMAN DISEASES; PROTEIN SCIENCE AND ENGINEERING; Contents; Preface; Abbreviations; Introduction to Small Heat Shock Proteins; Abstract; 1. Evolutionary Aspects; 2. Structure of small Stress Proteins; 3. Expression of sHSPs; 4. Post-Translational Modifications of sHSPs; 5. Interactions with Unfolding Proteins; 6. Interactions with Partner Proteins; 6.1. Interactions amongst sHSPs; 6.2. Interactions with the Cytoskeleton; 6.3. Interaction with Apoptotic Proteins; 6.4. Interaction with the Degradation Machinery; 7. Involvement of sHSPs in Diseases; Acknowledgments |
|
4. Mammalian HspB Neuroprotective Function May Be, at Least in Part, Independent on their "Chaperone-Like" Activity4.1. HspB1; 4.1.1. HspB1 and Huntington Disease; 4.1.2. HspB1 and Amyotrophic Lateral Sclerosis; 4.1-3. HspB1 and Tauopathies; 4.2. HspB5; 4.2.1. HspB5 and Congenital Cataract; 4.2.2. HspB5 and Parkinson; 4.2.3. HspB5 and Alexander Disease; 4.2.4. HspB5 and Multiple Sclerosis; 4.3. HspB8; 4.3.1. HspB8 and Alzheimer Disease; 4.3.2. HspB8 and Polyglutamine Disorders; Conclusion; References |
|
Functional Symbiosis between the Intermediate Filament Cytoskeleton and Small Heat Shock ProteinsAbstract; 1. The Evolutionary Context -- Bacterial Cytoskeleton, Stress and the Origins of the SIF Complex; 2. The Cytoskeleton -- The Key to Cell Mechanics and Resisting Stress; 3. Intermediate Filaments are Bona Fide Stress Proteins and Symbiotic Partners in the SIF Complex; 4. sHSP Interactions with IFs; 5. Lessons From IF Based Diseases; 6. Interaction of sHSPs with Other Client Proteins of the Cytoskeleton; 6.1. Actin Cytoskeleton; 6.2. Myosin Interactions -- Preserving ATPase Activity |
|
6.3. The Third Filament System of Muscle -- Titin6.4. Cadherin -- Kidney Specific (Ksp) -- Interactions; 6.5. Microtubules; 7. Filament Binding Sites; Conclusion; Acknowledgments; References; The Two Lens Structure Proteins, A-Crystallin (HspB4) and B-Crystallin (HspB5), Control Apoptosis through Regulation of Multiple Signaling Transduction Pathways; Abstract; Introduction; 1. The Biology of the Ocular Lens; 2. Apoptosis and Cataractogenesis in the Ocular Lens; 3. Discovery of the Anti-apoptotic Role of -Crystallins; 4. ( -Crystallins Prevents Developmental and Stress-Induced Apoptosis |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Heat shock proteins -- Physiological effect
|
|
Heat-Shock Proteins, Small -- physiology
|
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SCIENCE -- Life Sciences -- Biochemistry.
|
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Heat shock proteins -- Physiological effect.
|
| Form |
Electronic book
|
| Author |
Simon, Stéphanie
|
|
Arrigo, A.-P. (André-Patrick), 1947-
|
| ISBN |
9781616685348 |
|
1616685344 |
|
