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Title Heart failure management : the neural pathways / Edoardo Gronda, Emilio Vanoli, Alexandru Costea, editors
Published Cham : Springer, [2015]
©2016

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Description 1 online resource (viii, 216 pages) : illustrations (some color)
Contents Foreword; Contents; Part I: Current Heart Failure Therapies; 1: Introduction; References; 2: Therapies in Heart Failure, Tomorrow May Be Too Late; 2.1 The Heart Failure Pandemic and the "Halfway Technology" Swamp; 2.2 Current Heart Failure Therapy: The Achievements of Yesterday, the Hurdles of Today; 2.3 Heart Failure Therapy Tomorrow: Looking outside (Beyond) the Current Therapeutic Window; References; 3: Atrial Fibrillation, Heart Failure, and the Autonomic Nervous System; 3.1 Treatment of Atrial Fibrillation in the Heart Failure Population; 3.2 Autonomic Nervous System and AF
3.3 Ganglionic Plexi: Autonomic Modulation in the Treatment of Atrial Fibrillation; 3.4 Renal Denervation; 3.5 Alternative Therapies for Neuromodulation; Conclusions; References; 4: Current Therapies for Ventricular Tachycardia: Are there Autonomic Implications of the Arrhythmogenic Substrate?; References; Part II: The Autonomic Regulation and Dis- regulation of the Heart: Pathophysiology in Heart Failure; 5: "The Autonomic Nervous System Symphony Orchestra": Pathophysiology of Autonomic Nervous System and Analysis of Activity Frequencies; 5.1 Introduction; 5.2 Methodologies
5.2.1 General Considerations; 5.2.2 Muscle Sympathetic Nerve Activity (MSNA); 5.2.3 Heart Rate Variability; 5.2.3.1 Linear Analysis; 5.2.3.2 Nonlinear Analysis; 5.2.3.3 Symbolic Analysis; References; 6: Autonomic Pathophysiology After Myocardial Infarction Falling into Heart Failure; 6.1 Introduction; 6.2 The History; 6.3 Physiopathology of the Sympathetic Activation; 6.4 Nerve Sprouting After Myocardial Injury; 6.5 NGF Changes following an Ischemic Injury: From Short-Term to Long-Term Events; 6.6 From Acute Myocardial Injury to Chronic Heart Failure through Cardiac Remodeling
6.7 Molecular Pathophysiology of Cardiac Sympathetic Innervation Conclusions; References; 7: Cardiovascular Serenade: Listening to the Heart; 7.1 Introduction; 7.2 Heart Rate Variability; 7.3 Intrathoracic Impedance Measurement; 7.4 Implantable Hemodynamic Monitoring; 7.5 CHAMPION Trial; 7.6 CHAMPION Trial Results: Benefits of Listening to Central Hemodynamic Data; Conclusions; References; 8: Whispering During Sleep: Autonomic Signaling During Sleep, Sleep Apnea, and Sudden Death; 8.1 The Cardiovascular System and Sleep Architecture
9: Cerebral Aging: Implications for the Heart Autonomic Nervous System Regulation; 9.1 Central Control of Sympathetic Outflow; 9.2 Gangliar Level Control; 9.3 Nerve Ending Level: Presynaptic Control and Postsynaptic Signaling; 9.3.1 Presynaptic Control; 9.3.2 Postsynaptic Signaling; 9.4 The Baroreceptor Reflex; 9.5 Plasticity of the Autonomic Nervous System, the Role of Neurotrophins; References; Part III: Modulation of Autonomic Function in Heart Failure; 10: The Autonomic Cardiorenal Crosstalk: Pathophysiology and Implications for Heart Failure Management; 10.1 Introduction
Summary This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessive adrenergic activation in heart failure syndrome, the underlying abnormalities of adrenergic control remain unaltered and can still cause progression to unmanageable end-stage heart failure. New therapeutic pathways are therefore being explored with a view to developing interventions that can directly modulate adrenergic over-activity and restore a more appropriate balance in neural control of the cardiovascular system. The book opens by examining current heart failure therapies. Advances in our understanding of autonomic regulation/dysregulation in heart failure are then discussed in detail, in the context of the search for more effective therapies. A concluding section addresses the role of autonomic nervous system denervation in heart failure. The authors are top scientists from leading research centers
Notes Online resource; title from PDF title page (SpringerLink, viewed January 5, 2016)
Subject Heart failure.
Cardiac arrest.
Heart Failure
Heart Arrest
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cardiac arrest.
Heart failure.
Genre/Form Electronic books
Form Electronic book
Author Gronda, Edoardo, editor.
Vanoli, Emilio, 1954- editor.
Costea, Alexandru, editor.
ISBN 9783319249933
3319249932