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Author Marín-García, José, 1936-

Title Aging and the heart : a post-genomic view / José Marín-García ; with the collaboration of Michael J. Goldenthal, Gordon W. Moe
Published New York : Springer, 2008
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Description 1 online resource (xvii, 568 pages) : illustrations
Contents Part I: Introduction to a post-genomic view of aging and the aging heart. Post-genomic view of aging: definition, theories and observations ; Overview of cardiovascular aging -- Part II: Methodologies, cardiac phenotypes and adaptation. Molecular and cellular methodologies: a primer ; Molecular and cellular phenotypes of cardiovascular aging -- Part III: Aging of the cardiovasculature and related systems. Aging of the vasculature and related systems ; Aging and the cardiovascular-related systems -- Part IV: Cardiovascular diseases in aging. Cardiomyopathy and heart failure in aging ; Atherosclerosis, hypertension and aging ; Metabolic syndrome, diabetes and cardiometabolic risks in aging ; Gender and cardiovascular diseases in aging ; Cardiac dysrhythmias and channelopathies in aging -- Part V: Genetics. Genetics of life span: lessons from model organisms ; Profiling the aging cardiovascular system: transcriptional, proteomic, SNPs, gene mapping and epigenetics analysis -- Part VI: Therapies. Translational research: gene, pharmacogenomics and cell-based therapy in the aging heart ; Nutrition and exercise in cardiovascular aging: metabolic and pharmacological interventions -- Part VII: The future of aging research. Aging and the frontier ahead
Summary Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes, which along the way contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. Several plausible theories have been considered to explain aging, e.g., evolution, free radical, somatic mutation, etc; and at this time it is most likely that these different theories are intertwined with each other without a definitive "winner," reflecting a mixture of genetic and epigenetic elements found in most aged individuals with card
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Heart -- Aging.
Heart -- Diseases -- Genetic aspects.
Heart -- Diseases -- Molecular aspects.
Cardiovascular Diseases -- genetics.
Cardiovascular Diseases -- physiopathology.
Aging -- physiology.
Form Electronic book
Author Goldenthal, Michael J.
Moe, Gordon W.
LC no. 2007931956
ISBN 0387740716 (hbk.)
0387740724
9780387740713 (hbk.)
9780387740720