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Title Heart rate and rhythm : molecular basis, pharmacological modulation and clinical implications / Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti, Editors
Published Berlin ; Heidelberg ; New York : Springer, ©2011


Description 1 online resource (xxii, 678 pages) : illustrations
Contents pt. 1. Normal cardiac rhythm and pacemaker activity -- pt. 2. Modeling -- pt. 3. Cardiac development and anatomy -- pt. 4. Mechanisms of acquired arrhythmia -- pt. 5. Mechanisms of inherited arrhythmia -- pt. 6. Role of specific channels and transporters in arrhythmia -- pt. 7. Drugs and cardiac arrhythmia
Summary Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Heart beat.
Heart Rate -- physiology
Arrhythmias, Cardiac -- physiopathology
Heart Conduction System -- cytology
Ion Channels -- physiology
Anti-Arrhythmia Agents -- therapeutic use
Heart Rate
Heart beat
Form Electronic book
Author Tripathi, Onkar N
Ravens, Ursula.
Sanguinetti, Michael C.
ISBN 9783642175756