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Title Heart rate slowing by IF current inhibition / volume editors, John Camm, Michal Tendera
Published Basel ; New York : Karger, 2006


Description 1 online resource (viii, 115 pages)
Series Advances in cardiology, 0065-2326 ; v. 43
Advances in cardiology ; v. 43. 0065-2326
Contents Heart rate: a risk factor for cardiac diseases and outcomes? Pathophysiology of cardiac diseases and the potential role of heart rate slowing / Lanza, G.A., Fox, K., Crea, F. -- IF current inhibition: cellular basis and physiology / Mangoni, M.E., Marger, L., Nargeot, J. -- Heart rate reduction by pharmacological IF current inhibition / Cargnoni, A. [and others] -- Clinical perspectives of heart rate slowing for coronary event reduction and heart failure / Danchin, N., Kadri, Z. -- Clinical effect of 'pure' heart rate slowing with a prototype IF current inhibitor: placebo-controlled experience with ivabradine / Borer, J.S. -- Heart rate slowing versus other pharmacological antianginal strategies. Results of comparative studies / Diaz, A., Tardif, J.-C. -- Novel IF current inhibitor ivabradine: safety considerations / Savelieva, I., Camm, A.J. -- Heart rate slowing for myocardial dysfunction/heart failure. Rationale and preclinical studies / Mulder, P., Thuillez, C. -- Future directions: what data do we need? / Tendera, M
Summary This book unfolds the history of the discovery of the transmembrane channel which is responsible for the 'funny' or If current, the primary modulator of heart rate. Inhibition of this current leads to slowing of the heart rate, which is an important component of the successful management of angina pectoris. Recently, Ivabradine, a specific and selective inhibitor of the If current, has been developed as an antianginal agent which has been shown to be at least as effective as both beta-blockers and calcium channel blockers for the treatment of angina. The development, efficacy and complications
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Angina pectoris.
Heart beat.
Heart conduction system.
Ion channels.
Heart Rate -- drug effects
Heart Rate
Heart Conduction System
Ion Channels
Heart Diseases -- drug therapy
Heart Rate -- physiology
Ion Channels -- drug effects
Membrane Potentials -- drug effects
HEALTH & FITNESS -- Diseases -- Heart.
MEDICAL -- Cardiology.
Angina pectoris
Heart beat
Heart conduction system
Ion channels
Angina pectoris -- Herzfrequenz -- Inhibition -- Pharmakotherapie -- Aufsatzsammlung.
Herzfrequenz -- Inhibition -- Angina pectoris -- Pharmakotherapie -- Aufsatzsammlung.
Pharmakotherapie -- Herzfrequenz -- Inhibition -- Angina pectoris -- Aufsatzsammlung.
Form Electronic book
Author Camm, A. John.
Tendera, Micha?
ISBN 9781429468343