Title Handbook of mouse mutations with skin and hair abnormalities : animal models and biomedical tools / edited by John P. Sundberg

Published Boca Raton : CRC Press, 2020

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Description 1 online resource Series CRC series in dermatology CRC series in dermatology. Contents Cover -- Title Page -- Copyright Page -- Series Page -- The Editor -- Contributors -- Table of Contents -- Part I: Biology of Skin and Hair of Laboratory Mice and Human Beings -- Introduction -- Chapter 1: Applications and Needs of Models for Dermatological Research -- Chapter 2: Inbred Laboratory Mice as Animal Models and Biomedical Tools: General Concepts -- Chapter 3: The Jackson Laboratory Mouse Mutant Resource -- Chapter 4: Hair Follicle Stem Cells -- Chapter 5: The Mouse Skin as a Model for Chemical Carcinogenesis -- Chapter 6: Viral Induced Skin Tumors in Mice Chapter 7: Hair Types and Subtypes in the Laboratory Mouse -- Chapter 8: Growth Factors and Cutaneous Pathology -- Chapter 9: Transgenic Mice with Cytokine Mutations Affecting the Skin -- Chapter 10: Epidermal Keratins -- Chapter 11: Hair Follicle Keratins -- Chapter 12: Keratinocyte Cultures as Models for Dermatological Disease -- Chapter 13: Mouse Mutations with Endocrine Functional Consequences -- Chapter 14: The Immune System in Cutaneous Disease: the Search for a Mouse Model of the Immunopathology of Psoriasis -- Part II: Animal Models of Genetic Based Skin Diseases Section A: Mouse Single Gene Mutations -- Introduction -- Chapter 1: The Adrenocortical Dysplasia (acd) Mutation, Chromosome 8 -- Chapter 2: The Angora (go) Mutation, Chromosome 5 -- Chapter 3: The Asebia (ab, abJ) Mutations, Chromosome 19 -- Chapter 4: The Atrichosis (at) Mutation, Chromosome 10 -- Chapter 5: The Balding (bal) Mutation, Chromosome 18 -- Chapter 6: The Bare-Patches (Bpa) Mutation, Chromosome X -- Chapter 7: The Bareskin (Bsk) Mutation, Chromosome 11 -- Chapter 8: The Beige (bg) Mutation, Chromosome 13 -- Chapter 9: The Caracul (Ca and Cad) Mutations, Chromosome 15 Chapter 10: The Chronic Proliferative Dermatitis (cpd) Mutation, Chromosome ? -- Chapter 11: The Crinkled (cr) Mutation, Chromosome 13 -- Chapter 12: The Curly-Whiskers (cw) Mutation, Chromosome 9 -- Chapter 13: The Depilated (dep) Mutation, Chromosome 4 -- Chapter 14: The Downless (dl) and Sleek (Dlslk) Mutations, Chromosome 10 -- Chapter 15: The Ferrochelatase Deficiency (FechmlPas) Mutation, Chromosome 18 -- Chapter 16: The Flaky Skin (fsn) Mutation, Chromosome ? -- Chapter 17: The Flaky Tail (ft) Mutation, Chromosome 3 -- Chapter 18: The Frizzy (fr) Mutation, Chromosome 7 Chapter 19: The Fuzzy (fz) Mutation, Chromosome 1 -- Chapter 20: The Greasy (Gs) Mutation, Chromosome X -- Chapter 21: The Hair Interior Defect (hid) Mutation, Chromosome ? -- Chapter 22: The Hairless (hr) and Rhino (hrrh) Mutations, Chromosome 14 -- Chapter 23: The Hair Patches (Hpt) Mutation, Chromosome 4 -- Chapter 24: The Hairy Ears (Eh) Mutation, Chromosome 15 -- Chapter 25: The Harlequin (Hq) Mutation, Chromosome X -- Chapter 26: The Ichthyosis (ic) Mutation, Chromosome 1 -- Chapter 27: The Lethal Milk (Im) Mutation, Chromosome 2 -- Chapter 28: The Lustrous (It) Mutation, Chromosome 11 Summary Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system Notes John P. Sundberg, D.V.M., Ph.D., is Head of the Pathology program at the Jackson Laboratory in Bar Harbor, Maine. Dr. Sundberg graduated in 1973 from the University of Vermont with a B.S. degree in Animal Science (summa cum laude) and obtained his D.V.M. degree in 1977 from Purdue University School of Veterinary Medicine, West Lafayette, Indiana. Following a brief period in private practice. Dr. Sundberg earned a Ph.D. degree in comparative pathology in 1981 from The University of Connecticut in Storrs. Dr. Sundberg served as an assistant professor at the University of Illinois College of Veterinary Medicine from 1981 to 1986. In 1986 he assumed his present position. Dr. Sundberg is a diplomate of the American College of Veterinary Pathologists. He is a member of the American Veterinary Medical Association, American Association for Laboratory Animal Science, Society for Investigative Dermatology, Hair Research Society, New England Veterinary Pathology Colloquy, and the Maine Veterinary Medical Association. Dr. Sundberg has been the recipient of research grants from the National Institutes of Health, American Cancer Society, National Alopecia Areata Foundation, and private industry. He has published over 125 research and clinical papers, 50 technical bulletins, and 15 book chapters. His current major research interests relate to mouse mutations as models of human and animal diseases, the comparative pathology and molecular evolution of nonhuman papillomaviruses, and spontaneous diseases of inbred laboratory mice Subject Skin -- Diseases -- Animal models -- Handbooks, manuals, etc Hair -- Diseases -- Animal models -- Handbooks, manuals, etc Mice as laboratory animals -- Handbooks, manuals, etc Mice -- Genetics -- Handbooks, manuals, etc Mice -- Diseases -- Handbooks, manuals, etc MEDICAL / Research SCIENCE / Life Sciences / Genetics & Genomics SCIENCE / Life Sciences / General Mice as laboratory animals Mice -- Diseases Mice -- Genetics Skin -- Diseases -- Animal models Genre/Form Electronic books Handbooks and manuals Form Electronic book Author Sundberg, John P., editor. ISBN 9781000099300 100009930X 9781003068952 1003068952 9781000120998 1000120996 9781000142327 1000142329

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