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Title Current indications for growth hormone therapy / volume editor, Peter C. Hindmarsh
Edition 2nd, rev. ed
Published Basel ; New York : Karger, 2010


Description 1 online resource (vii, 129 pages) : illustrations
Series Endocrine development, 1421-7082 ; v. 18
Endocrine development ; v. 18. 1421-7082
Contents Clinical trials : planning and analysis / Farewell, V.T., Cook, R.J. -- The evidence base for growth hormone effectiveness in children / Kelnar, C.J.H. -- Safety of recombinant human growth hormone / Carel, J.-C., Butler, G. -- Diagnosis of growth hormone deficiency / Webb, E.A., Dattani, M.T. -- Biological determinants of responsiveness to growth hormone : pharmacogenomics and personalized medicine / Mullis, P.-E. -- Clinical considerations in using growth hormone therapy in growth hormone deficiency / Ranke, M.B. -- Current indications for growth hormone therapy for children and adolescents / Richmond, E., Rogol, A.D. -- GH use in the transition of adolescence to adulthood / Mauras, N
Summary Growth hormone (GH) has been used therapeutically for over 50 years. Since the development of a nearly unlimited supply of recombinant human GH in the mid-1980s, children with less severe GH deficiency can also profit from GH replacement therapy. Careful and accurate diagnosis and specific dosing, both essential to ensure normal height development, require the clinician to understand the finer points of clinical trials, to acquire quality evidence and assess the benefits of therapeutic intervention. Furthermore, genetic and environmental factors influencing GH sensitivity and responsiveness need to be taken into account. In this second edition all these aspects are covered in depth. Clinical examination, detailed auxological measurements, bone age assessment, molecular analysis and neuro-radiological evaluation as well as an adaptive strategy of dosing focusing on a patient's individual responsiveness are discussed in detail. This volume of Endocrine Development is essential reading for pediatric endocrinologists, pediatricians and clinical nurse specialists involved in GH therapy
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Somatotropin -- Therapeutic use
Human beings.
Growth Disorders -- drug therapy
Bone Diseases, Developmental -- drug therapy
Hormone Replacement Therapy -- methods
Human Growth Hormone -- deficiency
Human Growth Hormone -- therapeutic use
Noonan Syndrome -- drug therapy
Homo sapiens (species)
Somatotropin -- Therapeutic use
Form Electronic book
Author Hindmarsh, P. C. (Peter C.)
S. Karger (Firm)
ISBN 9783805591959