Title Glycopeptide antibiotics / edited by Ramakrishnan Nagarajan

Published New York : M. Dekker, c1994

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Description 1 online resource (xiv, 423 pages : illustrations) Series Drugs and the pharmaceutical sciences ; v. 63 Drugs and the pharmaceutical sciences ; v. 63. Contents Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Preface -- Table of Contents -- Contributors -- 1. Glycopeptides: Classification, Occurrence, and Discovery -- I. Introduction -- II. Classification -- III. Occurrence -- IV. Discovery and Screening -- V. Conclusion -- VI. Addendum -- References -- 2. Separation Methodology -- I. Introduction -- II. Classic Methods for Extraction and Purification -- III. Affinity Chromatography -- IV. Preparative Reversed-Phase HPLC -- V. General Glycopeptide Antibiotic Isolation Scheme -- VI. Analytical Separation Techniques VII. Conclusions -- References -- 3. Approaches to the Synthesis of the Vancomycin Aglycones -- I. Introduction -- II. Degradation Studies: Formation of Vancomycin Aglycone and Further Degradation to Amino Acid Constituents -- III. Synthesis Challenge -- IV. Model Studies: Approaches to the Synthesis of the Vancomycin Binding Pocket -- V. Synthesis of the Amino Acid Substituents -- VI. Synthesis of Vancomycin and Ristocetin Subunits -- VII. Oxidative Phenolic Coupling Studies -- VIII. Future Prospects -- IX. Conclusion -- X. Epilogue -- References -- 4. Chemistry of Carbohydrate Components I. Introduction -- II. Composition and Structural Elucidation of the Carbohydrate Units by Chemical Methods -- III. Chemical Synthesis of the Aminodeoxy Sugars -- IV. Synthesis of the Oligosaccharide Side Chains -- Abbreviations -- References -- 5. Structure-Activity Relationships of Vancomycin Antibiotics -- I. Introduction -- II. SAR of the Core Heptapeptide Amino Acids -- III. SAR of Semisynthetic Glycopeptide Antibiotics -- IV. SAR and Modes of Action -- V. Conclusions -- References -- 6. Resistance and Mode of Action -- I. Mechanism of Action of Vancomycin and Other Glycopeptides II. Glycopeptide Resistance -- References -- 7. Analytical Quantitation and Characterization -- I. Vancomycin BioanaJytical Methodologies -- II. Vancomycin Characterization Methodologies -- III. Characterization of Other Glycopeptides -- References -- 8. Teicoplanin -- I. Discovery -- II. Chemistry -- III. Fermentation -- IV Antimicrobial Activity -- V. Toxicology -- VI. Pharmacokinetics -- VII. Place of Teicoplanin in Therapy -- References -- 9. Vancomycin: A Clinical Overview -- I. Pharmacokinetics -- II. Clinical Efficacy -- III. Vancomycin Safety -- IV The Future -- References -- Epilogue Summary "Describing all known assays used to discover new glycopeptide antibiotics, this outstanding reference discusses practical techniques for screening, isolating, and analyzing glycopeptide antibiotics - correlating structure-activity relationships with the mode of action." "Classifying glycopeptide antibiotics according to differences in the chemical structure of the core heptapeptide aglycone, Glycopeptide Antibiotics examines every relevant chemical aspect of the carbohydrate components of glycopeptide antibodies ... details the purification of glycopeptide antibodies from fermentation broths ... contains an exhaustive survey of synthetic routes to the 3-amino-2,3,6-trideoxyhexoses ... reviews advances made towards the total synthesis of vancomycin and other similar chemical structures ... investigates the analytical quantitation, characterization, pharmacokinetics, clinical uses, and safety profile of vancomycin and related glycopeptides ... delineates the discovery, chemistry, antimicrobial activity, pharmacokinetics, and toxicology of teicoplanin ... explores the problem of resistance with glycopeptide antibodies ... and much more." "Exhaustively referenced furnishing over 1650 literature citations, Glycopeptide Antibiotics is an invaluable resource for industrial, clinical, and research pharmacists; pharmacologists; organic and medicinal chemists; pharmaceutical research and development managers; microbiologists; and graduate students in these disciplines."--BOOK JACKET Bibliography Includes bibliographical references and index Subject Glycopeptide antibiotics. Vancomycin. Antibiotics, Glycopeptide Vancomycin Vancomycin Glycopeptide antibiotics Form Electronic book Author Nagarajan, Ramakrishnan, 1931- LC no. 94000585 ISBN 9781000148329 1000148327 9781000105117 1000105113

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