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Title Glutathione / edited by Leopold Flohe
Published Boca Raton, FL : CRC Press, 2018


Description 1 online resource (411 pages)
Series Oxidative stress and disease
Oxidative stress and disease.
Contents 880-01 Biosynthesis of glutathione and its regulation / Henry J. Forman, Terrance J. Kavanagh and Hongqiao Zhang -- Renal glutathione transport : roles in redox homeostasis, cytoprotection and bioactivation / Lawrence H. Lash -- The catalytic mechanism of glutathione peroxidases / Laura Orian, Giorgio Cozza, Matilde Maiorino, Stefano Toppo and Fulvio Ursini -- GPx1-dependent regulatory processes / Diane E. Handy and Joseph Loscalzo -- GPx1 and diabetes / Holger Steinbrenner and Lars-Oliver Klotz -- GPx2 : role in physiology and carcinogenesis / Anna P. Kipp -- GPx4 : from prevention of lipid peroxidation to spermatogenesis and back / Fulvio Ursini, Antonella Roveri and Matilde Maiorino -- Thiols, glutathione, GPx4 and lipid metabolism at the crossroad of cell death and survival / José Pedro Friedman Angeli, Valerian E. Kagan and Marcus Conrad -- Peroxiredoxin 6 as glutathione peroxidase / Yefim Manevich -- Glutathione peroxidases and the thyroid gland / Lutz Schomburg -- Glutathione-S-transferases / Bengt Mannervik and Birgitta Sjödin -- Protein S-glutathionylation and glutathione S-transferase P / Kenneth D. Tew -- The role of glutathione in biosynthetic pathways and regulation of the eicosanoid metabolism / Ralf Morgenstern, Leopold Flohé, Jesper Haeggström and Per-Johan Jakobsson -- Nitric oxide and S-nitrosoglutathione / Iain L.O. Buxton and Scott D. Barnett -- The catalytic mechanism of glutaredoxins / Linda Liedgens and Marcel Deponte -- The role of glutaredoxins in the brain / Carsten Berndt, Anna Dorothee Engelke, Lars Bräutigam and Klaudia Lepka -- Biosynthesis of polyamine-glutathione derivatives in enterobacteria and kinetoplastida / Marcelo A. Comini -- Trypanothione functions in kinetoplastida / Martin Hugo, Madia Trujillo, Lucía Piacenza and Rafael Radi -- Mycothiol, a low-molecular-weight thiol drafted for oxidative stress defense duty / Leonardo Astolfi Rosado, Brandán Pedre and Joris Messens -- The role of bacillithiol / Haike Antelmann
880-01/$1 251 Linda Liedgens and Marcel Deponte Chapter 16 The Role of Glutaredoxins in the Brain ... 263 Carsten Berndt, Anna Dorothee Engelke, Klaudia Lepka, and Lars Bräutigam Part V Glutathione Derivatives and Substitutes in Pathogenic Microorganisms Chapter 17 Biosynthesis of Polyamine・Glutathione Derivatives in Enterobacteria and Kinetoplastida ... 285 Marcelo A. Comini Chapter 18 Trypanothione Functions in Kinetoplastida ... 307 Martín Hugo, Madia Trujillo, Lucía Piacenza, and Rafael Radi Chapter 19 Mycothiol, a Low-Molecular-Weight Thiol Drafted for Oxidative Stress Defense Duty ..
Summary This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Glutathione -- Congresses
Glutathione -- Metabolism -- Congresses
Oxidative stress.
Glutathione -- metabolism
Glutathione -- physiology
Glutathione -- biosynthesis
Oxidative Stress
SCIENCE -- Life Sciences -- Biochemistry.
Oxidative stress
Glutathione -- Metabolism
Genre/Form Conference papers and proceedings
Form Electronic book
Author Flohé, L. (Leopold), 1938- editor.
ISBN 9781351261753