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Title Facilitative glucose transporters in articular chondrocytes : expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines / Ali Mobasheri [and others]
Published Berlin : Springer Verlag, 2008

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Description 1 online resource (vi, 88 pages) : illustrations
Series Advances in anatomy, embryology, and cell biology ; 200
Advances in anatomy, embryology, and cell biology ; 200.
Contents Introduction -- Articular cartilage: structure, function and pathophysiology -- Does arthritis have a nutritional aetiology? -- Metabolic dysfunction in arthritis -- Glucose: an essential metabolite and structural precursor for articular cartilage -- Mammalian sugar transporter families: GLUT and SGLT -- Molecular diversity of facilitative glucose transporters in articular chondrocytes -- Regulation of glucose transport by non-steroidal anti-inflammatory drugs (NSAIDs) -- Glucose transporters in the intervertebral disc -- Glucose transporter expression and regulation in embryonic and mesenchymal stem cells -- Concluding remarks
Summary Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans
Bibliography Includes bibliographical references (pages 69-84) and index
Notes Print version record
Subject Glucose.
Articular cartilage.
Cartilage cells.
Cytokines.
Dextrose.
Glucose Transport Proteins, Facilitative -- metabolism
Glucose
Cartilage, Articular
Chondrocytes
Cytokines
Arthritis -- metabolism
Chondrocytes -- metabolism
SCIENCE -- Chemistry -- Organic.
Chondrocytes -- metabolism.
Glucose.
Articular cartilage.
Cartilage cells.
Cytokines.
Glucose Transport Proteins, Facilitative -- metabolism.
Arthritis -- metabolism.
Biom├ędecine.
Sciences de la vie.
Dextrose
Articular cartilage
Cartilage cells
Cytokines
Glucose
Form Electronic book
Author Mobasheri, A. (Ali), editor.
ISBN 9783540788997
3540788999
3540788980
9783540788980