Title Facilitative glucose transporters in articular chondrocytes : expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines / Ali Mobasheri [and others]

Published Berlin : Springer Verlag, 2008

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Description 1 online resource (vi, 88 pages) : illustrations Series Advances in anatomy, embryology, and cell biology ; 200 Advances in anatomy, embryology, and cell biology ; 200. Contents Introduction -- Articular cartilage: structure, function and pathophysiology -- Does arthritis have a nutritional aetiology? -- Metabolic dysfunction in arthritis -- Glucose: an essential metabolite and structural precursor for articular cartilage -- Mammalian sugar transporter families: GLUT and SGLT -- Molecular diversity of facilitative glucose transporters in articular chondrocytes -- Regulation of glucose transport by non-steroidal anti-inflammatory drugs (NSAIDs) -- Glucose transporters in the intervertebral disc -- Glucose transporter expression and regulation in embryonic and mesenchymal stem cells -- Concluding remarks Summary Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans Bibliography Includes bibliographical references (pages 69-84) and index Notes Print version record Subject Glucose. Articular cartilage. Cartilage cells. Cytokines. Dextrose. Glucose Transport Proteins, Facilitative -- metabolism Glucose Cartilage, Articular Chondrocytes Cytokines Arthritis -- metabolism Chondrocytes -- metabolism SCIENCE -- Chemistry -- Organic. Chondrocytes -- metabolism. Glucose. Articular cartilage. Cartilage cells. Cytokines. Glucose Transport Proteins, Facilitative -- metabolism. Arthritis -- metabolism. Biomédecine. Sciences de la vie. Dextrose Articular cartilage Cartilage cells Cytokines Glucose Form Electronic book Author Mobasheri, A. (Ali), editor. ISBN 9783540788997 3540788999 3540788980 9783540788980

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