| Description |
1 online resource (viii, 240 pages) : illustrations |
| Series |
Frontiers in diabetes ; vol. 13 |
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Frontiers in diabetes ; vol. 13.
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| Contents |
Design of the Entero-Insular Axis / W. Creutzfeldt -- Proglucagon Gene Structure and Regulation of Expression / J.F. Habener -- Posttranslational Processing of Proglucagon and Postsecretory Fate of Proglucagon Products / J.J. Holst, C. Orskov and B. Hartmann [and others] -- Morphological Aspects of GLP-1 Expression in the Intestine / R. Eissele -- Release of GLP-1 into the Circulation / P.L. Brubaker -- Glucagon-Like Peptide-1 Receptor in Relation to Its Ligand / R. Goke, A. Hareter and T. Vahl [and others] -- Effects of GLP-1 on Islet Hormone Secretion: Experimental Studies / H.C. Fehmann -- In vivo Regulation of Human Islet Hormone Secretion by Glucagon-Like Peptide-1 / D.A. D'Alessio and J.W. Ensinck -- Signal Transduction of GLP-1 / H.-P. Bode and B. Goke -- Islet Genes Regulated by GLP-1 / H.C. Fehmann -- Glucagon-Like Peptide-1 and the Glucose Competence Concept of Pancreatic Beta-Cell Function / G.G. Holz and C.A. Leech |
| Summary |
Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Glucagon-like peptide 1.
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Glucagon-Like Peptides -- metabolism
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Diabetes Mellitus -- drug therapy
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Glucagon -- metabolism
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Glucagon -- therapeutic use
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Peptide Fragments
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Glucagon-Like Peptide 1
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Glucagon-like peptide 1
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Peptides glucagon-like -- Métabolisme.
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Glucagon -- usage thérapeutique.
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Fragments peptidiques.
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Diabète -- Traitement médicamenteux.
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Glucagon -- Métabolisme.
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Glucagon-related-peptides
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Glucagon.
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Insuline -- Métabolisme.
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Diabète -- Chimiothérapie.
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Entéroglucagon.
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| Form |
Electronic book
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| Author |
Fehmann, H.-C. (Hans-Christoph)
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Göke, B. (Burkhard)
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S. Karger (Firm)
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| ISBN |
9783318019346 |
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3318019348 |
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