| Description |
1 online resource (xv, 322 pages) |
| Contents |
Preface -- Abbreviations -- Glossary -- Introduction -- pt. I. Gene and protein structure ; 1. Gene structures ; 2. Developmental expression ; 3. Gene regulation ; 4. Protein structure and functional domains ; 5. Enzymatic properties ; 6. Epitope maps -- pt. II. In vivo functions ; 7. The in vivo role of TNAP ; 8. Knockout mouse models -- pt. III. AP expression in health and disease ; 9. APs as physiological and disease markers ; 10. Neoplastic expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP isozymes -- pt. IV. Uses of APs in industry and biotechnology ; 11. Applications of recombinan APs ; 12. Use of APs in prodrug converting strategies ; 13. APs as therapeutic agents ; 14. APs in the food industry ; 15. Veterinary uses of AP determinations ; 16. Methodologies |
| Summary |
A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: The structure, regulation and expression of the AP genes; The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes; The phenotypic abnormalities of the different AP knockout mice; Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzym |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Alkaline Phosphatase -- genetics.
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Alkaline Phosphatase -- therapeutic use.
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Mammals -- genetics.
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Models, Animal.
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Models, Genetic.
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Alkaline phosphatase.
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| Form |
Electronic book
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| Author |
John Wiley & Sons.
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| ISBN |
3527310797 (print edition) |
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3527607471 (electronic bk.) |
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3527608060 (electronic bk.) |
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9783527310791 (print edition) |
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9783527607471 (electronic bk.) |
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9783527608065 (electronic bk.) |
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