Contributors; 1 Insertional Mutagenesis: A Powerful Tool in Cancer Research; 2 Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma; 3 Gene Discovery by MMTV Mediated Insertional Mutagenesis; 4 Chicken Models of Retroviral Insertional Mutagenesis; 5 Sleeping Beauty Models of Cancer; 6 Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials; 7 Bioinformatics of High-Throughput Insertional Mutagenesis; Index
Summary
The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials
