Title Polymeric gene delivery : principles and applications / edited by Mansoor M. Amiji

Published Boca Raton, Fla. : CRC Press, ©2005

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Description 1 online resource Contents Front cover; Preface; Contributors; Table of Contents; chapter 1; Introduction; Part I; chapter 2; Tissue- and Cell-Specific Targeting for the Delivery of Genetic Information; 2.1 Introduction; 2.2 Background Issues; 2.3 General Factors to Consider; 2.3.1 Viral Systems; 2.3.2 Nonviral Systems; 2.3.3 Immune Concerns; 2.3.4 Targeting Issues; 2.4 Targeting Cells and Tissues; 2.5 Topical Delivery Approaches; 2.6 Local Injection; 2.7 Vascular Targeting; 2.8 Cell-Based Targeting; 2.9 Conclusions; References; chapter 3; Biological Barriers to Gene Transfer; 3.1 Introduction; 3.2 Biological Barriers 3.2.1 Step 1: Reaching Target Cells3.2.1.1 Recognition by Specific Target Tissues; 3.2.1.2 Avoidance of Nonspecific Uptake; 3.2.1.3 Resistance to Degradation in the Systemic Circulation; 3.2.2 Step 2: Crossing Over the Cell Membrane; 3.2.3 Step 3: Nuclear Targeting; 3.2.4 Step 4: Regulation of Gene Expression; 3.2.4.1 Stable Retention of a Transgene; 3.2.4.2 Regulation of Transcription; 3.3 Conclusion; References; chapter 4; Cellular Uptake and Trafficking; 4.1 Introduction; 4.2 Viruses: Why Are They Such Efficient Delivery Systems?; 4.3 Cellular Barriers to DNA Delivery 4.3.1 Stability in Extracellular Compartments4.3.2 Association of DNA with the Cell Membrane; 4.3.3 Cellular Internalization; 4.3.3.1 Proton Sponge; 4.3.3.2 pH-Sensitive Liposomes; 4.3.3.3 Fusogenic Peptides; 4.3.4 Cytosolic Transport of DNA; 4.3.4.1 Metabolic Instability of DNA in the Cytosol; 4.3.5 Nuclear Localization of Plasmid DNA; 4.3.5.1 Nucleocytoplasmic Transport; 4.3.5.2 Nuclear Import of DNA; 4.3.5.3 Attempts to Increase the Efficiency of Nuclear DNA Uptake; 4.4 Current Approaches for Enhancing Gene Delivery; 4.4.1 Viral Vectors; 4.4.2 Chemical/Synthetic Nonviral Vectors 4.4.2.1 Liposomes4.4.2.2 DNA-Protein Conjugates; 4.4.3 Physical Methods of DNA Delivery; 4.4.3.1 Electroporation; 4.4.3.2 Direct DNA Injection and Microinjection; 4.4.3.3 Bombardment of DNA-Coated Particles; 4.4.4 Other Physical Approaches; 4.5 Conclusions; References; chapter 5; Pharmacokinetics of Polymer-Plasmid DNA Complex; 5.1 Introduction; 5.2 Pharmacokinetic Consideration of Macromolecules; 5.3 Basic Pharmacokinetic Properties of Naked Plasmid DNA; 5.3.1 Cellular Uptake Mechanism; 5.3.2 Tissue Distribution after Intravenous Injection; 5.4 Pharmacokinetics of Polymer-Plasmid DNA Complex 5.4.1 Cellular Uptake5.4.2 Interaction with Biological Components; 5.4.3 Tissue Distribution; 5.5 Pharmacokinetics of Targeted Polymer-Plasmid DNA Complex; 5.5.1 Fundamentals of Targeted Delivery; 5.5.2 Sugar-Mediated Targeting; 5.6 Conclusion; References; Part II; chapter 6; Poly(L-Lysine) and Copolymers for Gene Delivery; 6.1 Introduction; 6.2 Characteristics of PLL as a Gene Carrier; 6.3 PLL Conjugates; 6.3.1 PLL Conjugates for Low Cytotoxicity; 6.3.1.1 PLL-PEG Block Copolymer; 6.3.1.2 PEG-Grafted PLL; 6.3.1.3 PLL-Based Biodegradable Polymer Summary Introduction; Robert Langer, MIT, Cambridge, MAGENE DELIVERY: CHALLENGES AND OPPORTUNITIESTissue and Cell Specific Targeting for the Delivery of Genetic Information; Randall J. Mrsny, University of Wales, UKBiological Barriers to Gene Transfer; Yasufumi Kaneda, Osaka University, JapanCellular Uptake and Trafficking; Sujatha Dokka and Yon Rojanasakul, West Virginia University. Morgantown, WV, USAPharmacokinetics of Polymer/Plasmid DNA Complex; Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida, Kyoto University, JapanCONDENSING POLYMERIC SYSTEMSA. Non-Degradable PolymersPoly(L-Lysine) an Notes Title from PDF title page (viewed February 15, 2008) Bibliography Includes bibliographical references and index Subject Gene therapy. Polymeric drug delivery systems. Polymers. Genetic Therapy -- methods Genetic Therapy Drug Delivery Systems Gene Targeting -- methods Gene Transfer Techniques Genetic Vectors -- therapeutic use Polymers Pharmaceutical Vehicles polymers. PSYCHOLOGY -- Psychotherapy -- General. Polymers Gene therapy Polymeric drug delivery systems Polymeren. Gentherapie. Geprogrammeerde toediening. Moleculaire nanotechnologie. Form Electronic book Author Amiji, Mansoor M. ISBN 9780203500477 0203500474

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