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Author Arbuthnot, Patrick, author

Title Gene therapy for viral infections / Patrick Arbuthnot
Published Amsterdam : Elsevier Press is an imprint of Elsevier, 2015
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Description 1 online resource : color illustrations
Contents Front Cover; Gene Therapy for Viral Infections; Copyright; Dedication; Contents; Acknowledgments; Chapter 1 -- Essentials of Viruses and their Suitability for Treatment Using Gene Therapy; 1.1 GENE THERAPY; 1.2 ESSENTIALS OF VIRUSES; 1.3 VIRAL PATHOGENESIS OF DISEASE; 1.4 IMMUNE RESPONSES TO VIRUS INFECTIONS; 1.5 MUTATION OF VIRUSES; 1.6 CONTROL OF VIRAL INFECTION; 1.7 METHODS OF USING GENE THERAPY TO TREAT VIRAL INFECTIONS; REFERENCES; Chapter 2 -- Harnessing RNAi to Silence Viral Gene Expression; 2.1 INTRODUCTION; 2.2 BIOGENESIS OF MIRS IN MAMMALIAN CELLS
2.3 EXPLOITING RNAI TO SILENCE VIRAL GENE EXPRESSIONTO COUNTER VIRAL INFECTIONS; REFERENCES; Chapter 3 -- Engineering Sequence-Specific DNA Binding Proteins for Antiviral Gene Editing; 3.1 INTRODUCTION; 3.2 ZINC FINGER PROTEINS; 3.3 TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS; 3.4 HOMING ENDONUCLEASES; 3.5 CRISPR/CAS; 3.6 DELIVERY OF CUSTOMIZED SEQUENCE-SPECIFIC DNA BINDING PROTEINS FOR ANTIVIRAL THERAPEUTIC APPLICATION; 3.7 USE OF SITE-SPECIFIC DNA TARGETING FOR TREATMENT OF VIRAL INFECTIONS; 3.8 CONCLUSIONS; REFERENCES; Chapter 4 -- Viral Vectors for Delivery of Antiviral Sequences
4.1 INTRODUCTION4.2 ADENO-ASSOCIATED VIRAL VECTORS; 4.3 ADENOVIRAL VECTORS; 4.4 LENTIVIRAL AND RETROVIRAL VECTORS; 4.5 USE OF VIRAL VECTORS FOR DEVELOPING TREATMENT VIRAL INFECTIONS; 4.6 CONCLUSIONS; REFERENCES; Chapter 5 -- Delivery of Antiviral Nucleic Acids with Nonviral Vectors; 5.1 INTRODUCTION; 5.2 CONSIDERATIONS FOR OPTIMIZING NVV-MEDIATED DELIVERY OF THERAPEUTIC NUCLEIC ACIDS TO VIRUS-INFECTED CELLS; DELIVERED WITH NVVS; 5.4 CATEGORIES OF NVVS; 5.5 CONCLUSIONS; REFERENCES; Chapter 6 -- Gene Therapy for Chronic Hepatitis B Virus Infection; 6.1 INTRODUCTION
6.2 GENE THERAPY FOR HBV INFECTIONOF HBV INFECTION; SILENCING HBV REPLICATION; 6.5 GENE EDITING FOR THE INACTIVATION OF VIRAL CCCDNA; 6.6 CONCLUSIONS; REFERENCES; Chapter 7 -- Gene Therapy for Hepatitis C Virus Infection; 7.1 DISCOVERY OF HEPATITIS C VIRUS; OF HCV INFECTION; 7.3 HCV GENOME AND VIRAL REPLICATION; 7.4 MODELS OF HCV INFECTION; 7.5 CURRENT AND NEW HCV TREATMENT; 7.6 COUNTERING HCV WITH NUCLEIC ACIDS; 7.7 CONCLUSIONS; REFERENCES; Chapter 8 -- Gene Therapy for HIV-1 Infection; IN RESEARCH ON HIV; 8.2 EPIDEMIOLOGY OF HIV-1 INFECTION; 8.3 PROTEINS ENCODED BY HIV-1
8.4 REPLICATION OF HIV-18.5 PATHOGENESIS OF AIDS; HIV-1 INFECTION; 8.7 MODELS OF HIV-1 REPLICATION; 8.8 GENE THERAPY FOR HIV-1 INFECTION; 8.9 CONCLUSIONS; REFERENCES; Chapter 9 -- Gene Therapy for Respiratory Viral Infections; 9.1 INTRODUCTION; 9.2 RESPIRATORY SYNCYTIAL VIRUS; 9.3 INFLUENZA VIRUS; 9.4 SARS COV; VIRAL INFECTIONS; 9.6 CONCLUSIONS; REFERENCES; Chapter 10 -- Gene Therapy for Infection with Hemorrhagic Fever Viruses; 10.1 INTRODUCTION; 10.2 FILOVIRIDAE; 10.3 DENGUE VIRUS; FEVER VIRUSES; 10.5 CONCLUSIONS; REFERENCES
Chapter 11 -- Gene Transfer for Prophylaxis and Therapy of Viral Infections
Summary Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vec
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed June 5, 2015)
Subject Genetic Therapy.
Virus Diseases -- genetics.
Genetic Vectors -- genetics.
Virus diseases -- Gene therapy.
Form Electronic book
ISBN 0124114520 (electronic bk)
9780124114524 (electronic bk)