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Genes, T-Cell Receptor -- See Also Receptors, Antigen, T-Cell


Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains
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Genes, T-Cell Receptor : The T cell receptor factsbook / Marie-Paule Lefranc, GĂ©rard Lefranc  2001 1
 

Genes, T-Cell Receptor delta -- See Also Receptors, Antigen, T-Cell, gamma-delta


T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3)
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Genes, T-Cell Receptor delta : Gamma-delta T cells / volume editors, Paul R. Bergstresser, A. Takashima  2001 1
 

Genes, T-Cell Receptor gamma -- See Also Receptors, Antigen, T-Cell, gamma-delta


T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3)
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Genes, T-Cell Receptor gamma : Gamma-delta T cells / volume editors, Paul R. Bergstresser, A. Takashima  2001 1
 

Genes, TcR -- See Genes, T-Cell Receptor


DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression
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Genes, TcR delta -- See Genes, T-Cell Receptor delta


DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus
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Genes, TcR gamma -- See Genes, T-Cell Receptor gamma


DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus
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Genes, TP53 -- See Genes, p53


Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53
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Genes, Transforming -- See Oncogenes


Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene
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  Genes, Transgenic, Suicide -- 2 Related Subjects   2
Genes, Transgenic, Suicide   2
 

Genes, Tumor Suppressing -- See Genes, Tumor Suppressor


Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible
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Genes, Tumor Suppressor -- See Also Tumor Suppressor Proteins


Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development
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Genes, Tumor Suppressor   9
Genes, Tumor Suppressor -- drug effects : Maspin / [edited by] Mary J.C. Hendrix  2002 1
Genes, Tumor Suppressor -- physiology : Tumor suppressor genes. Volume 223, Part 2, Regulation, function, and medicinal applications / edited by Wafik S. El-Deiry  2003 1
 

Genes, v-Ha-ras -- See Genes, ras


Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein
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Genes, v-Ki-ras -- See Genes, ras


Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein
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Genes, v-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
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Genes, v-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
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  Genes, Viral -- 4 Related Subjects   4
Genes, Viral   4
Genes, Viral -- genetics   2
 

Genes, Wilms Tumor -- See Also Beckwith-Wiedemann Syndrome


A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities
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Genes, Wilms Tumor   2
 

Genes, X-Linked -- See Also Genetic Diseases, X-Linked


Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases
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Genesee Co., Mich -- See Genesee County (Mich.)


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Genesee College -- See Also the later heading Syracuse University


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Genesee County (Mich.) -- Newspapers.   6
Genesee County (N.Y.) -- Newspapers : Journal-register (Medina, N.Y.)  1970- 1
Genesee River Valley (Pa. and N.Y.) -- Biography : Mary Jemison / by James E. Seaver  2001 1
Genesee River Valley (Pa and NY) Community life History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa. and N.Y.) -- Ethnic relations -- History -- 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Indian captivities : Mary Jemison / by James E. Seaver  2001 1
Genesee River Valley (Pa and NY) Pioneers Biography : Mary Jemison / by James E. Seaver  2001 1
Genesee River Valley (Pa and NY) Power (Social sciences) History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Quakers History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Seneca Indians History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Seneca Indians Social life and customs 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Social change History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa. and N.Y.) -- Social life and customs -- 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley (Pa and NY) Witchcraft History 19th century : Seneca possessed : Indians, witchcraft, and power in the early American republic / Matthew Dennis  2010 1
Genesee River Valley United States   2
 

Genesee Valley (Pa. and N.Y.) -- See Genesee River Valley (Pa. and N.Y.)


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Geneseo (Ill.) -- Newspapers : The Geneseo republic  1859- 1
Genesis 1-3 Exegese Islam Adam Eva   2
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