The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia; Molecular Targeted Therapies in T-CellAcute Lymphoblastic Leukemia; Molecularly Targeted Therapy for Infant ALL; Targeted Therapeutic Approaches for AML; Acute Promyelocytic Leukaemia; Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy; Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML); Chronic Myeloid Leukemia: Pathophysiology and Therapeutics; Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes
Summary
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular 'drivers' can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies
