| Description |
1 online resource (xviii, 710 pages) : illustrations (some color) |
| Series |
Wiley InterScience electronic collection
|
| Summary |
The ability to deliver therapeutic genes effectively is the most important requirement for the success of gene therapy interventions. Representing the discipline's first authoritative text, Vector Targeting for Therapeutic Gene Delivery clearly presents the most recent advances in target definition technology and the principles underlying the rational design of targeted vectors for gene therapy. The book's first section focuses on transductional targeting strategies designed to achieve the selective delivery of the therapeutic gene by both nonviral and viral vectors; the second section discusses transcriptional targeting, in which the therapeutic gene is placed under the control of transcriptional regulatory sequences that are activated in the disease cells, but not in normal cells, and therefore target expression selectively to the tumor cell. Other sections consider the variety of strategies that can be employed to define appropriate cellular targeting moieties and strategies to monitor the extent of gene expression. This book also:*Provides a theoretical framework for advanced vector design*Integrates all of the allied sciences relevant to the study of vector targeting*Includes an expert's perspective on promising future therapeutic applicationsBiotechnology industry researchers, as well as individuals involved with the development of human gene therapies, will find Vector Targeting for Therapeutic Gene Delivery to be a vital addition to their professional libraries |
| Analysis |
Pharmacology pharmaceutical medicine Oncology Pharmaceutical medicinal chemistry |
| Notes |
This title is available on the World Wide Web. Editions may vary. Access is restricted to computers located within Mount Sinai or to those users eligible for remote access services |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Gene targeting.
|
|
Gene therapy.
|
|
Genetic vectors.
|
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Gene Expression Regulation, Viral -- genetics.
|
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Genetic Therapy -- methods.
|
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Genetic Vectors.
|
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Transduction, Genetic -- methods.
|
| Form |
Electronic book
|
| Author |
Curiel, David.
|
|
Douglas, Joanne T.
|
|
John Wiley & Sons, Ltd.
|
| ISBN |
0471234303 (electronic book) |
|
1280556471 |
|
9780471234302 (electronic book) |
|
9781280556470 |
|
(cloth ; alk. paper) |
|
(cloth ; alk. paper) |
|
