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gene activation. : Epigenetics and Assisted Reproduction : an Introductory Guide  2018 1
 

Gene Amplification -- See Also Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
  1
Gene amplification.   8
Gene amplification -- Laboratory manuals   5
Gene amplification -- Methodology. : PCR protocols : current methods and applications / edited by Bruce A. White  1993 1
 

Gene Analyses, Candidate -- See Genetic Association Studies


The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease
  1
 

Gene Analysis, Candidate -- See Genetic Association Studies


The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease
  1
 

Gene, APC -- See Genes, APC


Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers
  1
 

Gene, Artificial -- See Genes, Synthetic


Biologically functional sequences of DNA chemically synthesized in vitro
  1
 

Gene, Bacterial -- See Genes, Bacterial


The functional hereditary units of BACTERIA
  1
 

Gene banks (Genetic engineering) -- See Gene libraries


  1
Gene banks, Plant.   6
Gene banks, Plant -- Directories. : Temperate fruits and tree nuts : actinidia, amelanchier, carya, castanea, corylus ... and others / E.J. Bettencourt, J. Konopka  1989 1
Gene banks, Plant -- Great Britain. : The last great plant hunt : the story of Kew's Millennium Seed Bank / Carolyn Fry, Sue Seddon and Gail Vines  2011 1
 

Gene, BRCA1 -- See Genes, BRCA1


A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways
  1
 

Gene, BRCA2 -- See Genes, BRCA2


A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
  1
 

Gene, c-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Gene, c-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
  1
 

Gene, Cancer -- See Genes, Neoplasm


Genes whose abnormal expression, or MUTATION are associated with the development, growth, or progression of NEOPLASMS
  1
 

Gene, Cancer Suppressor -- See Genes, Tumor Suppressor


Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible
  1
gene changes. : Epigenetics and Assisted Reproduction : an Introductory Guide  2018 1
 

Gene Chip -- See Oligonucleotide Array Sequence Analysis


Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING
  1
 

Gene Chips -- See Oligonucleotide Array Sequence Analysis


Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING
  1
 

Gene Circuit -- See Gene Regulatory Networks


Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations
  1
  Gene circuits -- 2 Related Subjects   2
 

Gene cloning -- See Molecular cloning


  1
 

Gene Cluster -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
  1
 

Gene Clusters -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
  1
Gene Code : Biochimica et biophysica acta. Gene structure and expression  2007 1
 

Gene Copy Number -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
  1
 

Gene Copy Numbers -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
  1
 

Gene Delivery System -- See Gene Transfer Techniques


The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms
  1
 

Gene Delivery Systems -- See Gene Transfer Techniques


The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms
  1
 

Gene, Developmental -- See Genes, Developmental


Genes that determine the fate of a cell or CELLS in a region of the embryo during EMBRYONIC DEVELOPMENT
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Gene Discovery -- See Genetic Association Studies


The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease
  1
 

Gene Dosage -- See Also DNA Copy Number Variations


Stretches of genomic DNA that exist in different multiples between individuals. Many copy number variations have been associated with susceptibility or resistance to disease
  1
 

Gene Dosages -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
  1
 

Gene Drive -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
  1
 

Gene Drive System -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
  1
 

Gene Drive Systems -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
  1
 

Gene Drive Technologies -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
  1
Gene Drive Technology : Gene drives at tipping points precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations / Arnim von Gleich, Winfried Schröder, editors  2020 1
 

Gene Drives -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
  1
Gene drives. : Gene drives at tipping points precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations / Arnim von Gleich, Winfried Schröder, editors  2020 1
  Gene Duplication -- 2 Related Subjects   2
Gene Duplication : Genome duplication / Melvin L. DePamphilis, Stephen D. Bell  2011 1
 

Gene Duplications -- See Gene Duplication


Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES
  1
 

Gene Editing -- See Also CRISPR-Cas Systems


Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS
  1
Gene editing.   22
Gene Editing -- ethics   2
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