| Description |
1 online resource (232 pages) : illustrations |
| Contents |
The NF-kB Pathway: A Paradigm for Inducible Gene; Expression, S. Ghosh ; Structural Aspects of NF-kB and I•B Proteins, A. K. Moorthy, T. Huxford, and G. Ghosh ; Regulation of IKK, H. Häcker and M. Karin ; Control of NF-kB Activation by Ubiquitination, S. C. Ley and Y. Ben-Neriah ; Regulation of Nuclear NF-kB Action: A Key Role for Posttranslational Modification, L.F. Chen and W. C. Greene ; NF-kB in the Innate Immune System, M. S. Hayden and S. Ghosh ; NF-kB in the Adaptive Immune System: Lymphocyte Survival and Function, M. S. Hayden and S. Ghosh ; NF-kB and IKK as Key Mediators of Inflammation and Oncogenic Progression, A. S. Baldwin ; NF-kB and Associated Human Genetic Pathologies, A. Israël ; Regulating the Master Regulator NF-kB: From Natural Strategies to Rationally Designed Superdrugs, S. Withoff, V. Tergaonkar, and I. M. Verma ; Index |
| Summary |
Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is proving to be the most protean of all transcription factors. It has been shown to function in most cell types as a key regulator of a number of inducible genes. Research on the responsibilities and resulting pathologies of NF-kB has been prolific, but un |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
NF-kappa B (DNA-binding protein) -- Handbooks, manuals, etc
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Transcription factors -- Handbooks, manuals, etc
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Gene expression -- Handbooks, manuals, etc
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NF-kappa B (DNA-binding protein)
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NF-kappa B
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MEDICAL -- Genetics.
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Gene expression
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NF-kappa B (DNA-binding protein)
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Transcription factors
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| Genre/Form |
Electronic book
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Handbooks and manuals
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| Form |
Electronic book
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| Author |
Ghosh, Sankar, 1959-
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| LC no. |
2006013488 |
| ISBN |
9781420004274 |
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1420004271 |
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1280732709 |
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9781280732706 |
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