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Gene, c-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
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Gene, c-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
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Gene, Cancer -- See Genes, Neoplasm


Genes whose abnormal expression, or MUTATION are associated with the development, growth, or progression of NEOPLASMS
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Gene, Cancer Suppressor -- See Genes, Tumor Suppressor


Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible
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gene changes. : Epigenetics and Assisted Reproduction : an Introductory Guide  2018 1
 

Gene Chip -- See Oligonucleotide Array Sequence Analysis


Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING
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Gene Chips -- See Oligonucleotide Array Sequence Analysis


Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING
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Gene Circuit -- See Gene Regulatory Networks


Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations
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  Gene circuits -- 2 Related Subjects   2
 

Gene cloning -- See Molecular cloning


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Gene Cluster -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
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Gene Clusters -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
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Gene Code : Biochimica et biophysica acta. Gene structure and expression  2007 1
 

Gene Copy Number -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
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Gene Copy Numbers -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
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Gene Delivery System -- See Gene Transfer Techniques


The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms
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Gene Delivery Systems -- See Gene Transfer Techniques


The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms
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Gene, Developmental -- See Genes, Developmental


Genes that determine the fate of a cell or CELLS in a region of the embryo during EMBRYONIC DEVELOPMENT
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Gene Discovery -- See Genetic Association Studies


The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease
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Gene Dosage -- See Also DNA Copy Number Variations


Stretches of genomic DNA that exist in different multiples between individuals. Many copy number variations have been associated with susceptibility or resistance to disease
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Gene Dosages -- See Gene Dosage


The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage
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Gene Drive -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
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Gene Drive System -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
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Gene Drive Systems -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
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Gene Drive Technologies -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
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Gene Drive Technology. : Gene drives at tipping points precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations / Arnim von Gleich, Winfried Schröder, editors  2020 1
 

Gene Drives -- See Gene Drive Technology


The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population
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Gene drives. : Gene drives at tipping points precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations / Arnim von Gleich, Winfried Schröder, editors  2020 1
  Gene Duplication -- 2 Related Subjects   2
Gene Duplication : Genome duplication / Melvin L. DePamphilis, Stephen D. Bell  2011 1
 

Gene Duplications -- See Gene Duplication


Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES
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Gene Editing -- See Also CRISPR-Cas Systems


Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS
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Gene editing.   18
Gene Editing -- ethics   2
Gene editing -- Law and legislation : Regulation of genome editing in human iPS cells : a comparative legal analysis of national regulatory frameworks for IPSC-based cell/gene therapies / Hans-Georg Dederer, Gregor Frenken, editors  2022 1
Gene Editing -- methods : CRISPR-/Cas9 based genome editing for treating genetic disorders and diseases / editor, Luis María Vaschetto  2022 1
Gene editing -- Moral and ethical aspects   5
Gene editing -- Periodicals : Frontiers in genome editing  2020 1
Gene editing -- Technological innovations : Tailored humanity : a revolution in genetics / directed by Caroline Hocquard, Etienne Blanchon ; narrated by Jérémie Bernier ; produced by Altomedia  2018 1
  Gene-environment interaction -- 3 Related Subjects   3
Gene-Environment Interaction   11
 

Gene-Environment Interactions -- See Gene-Environment Interaction


The combined effects of genotypes and environmental factors together on phenotypic characteristics
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Gene, Epistatic -- See Epistasis, Genetic


A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes
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Gene, erbb2 -- See Genes, erbB-2


The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2
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  Gene expression -- 10 Related Subjects   10
Gene expression.   130
Gene expression -- Analysis : Environmental DNA : for biodiversity research and monitoring / Pierre Taberlet, Aurélie Bonin, Lucie Zinger, Eric Coissac  2018 1
Gene expression -- Analysis -- Automation. : Microarrays for an integrative genomics / Isaac S. Kohane, Alvin T. Kho, and Atul J. Butte  2003 1
Gene expression -- Congresses.   6
Gene expression -- Data processing.   2
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