Title Strategies for reducing drug and chemical residues in food animals : international approaches to residue avoidance, management, and testing / edited by Ronald Baynes, North Carolina State University, Raleigh, North Carolina, USA, Jim E. Riviere, Kansas State University, Manhattan, Kansas, USA

Published Hoboken, New Jersey : Wiley, [2014]

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Description 1 online resource Contents Cover; Title page; Copyright page; Preface; Contributors; 1 Importance of Veterinary Drug Residues; 1.1 Introduction; 1.2 Veterinary Drug Use in Livestock; 1.3 Quality Assurance Programs; 1.4 Adverse Human Health Effects of Drug Residues; 1.5 Withdrawal Time Determinations; 1.6 Antimicrobial Resistance; 1.7 Economic Impact of Drug Residues; References; 2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination of Withdrawal Periods for Animal Drugs; 2.1 Introduction; 2.2 Basic Pharmacokinetic Principles Underlying Drug Depletion 2.3 The Impact of PK on Drug Depletion2.4 Factors Influencing ADME; 2.5 Conclusion; References; 3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals for Establishing Withdrawal Periods and Milk Discard Times; 3.1 Introduction; 3.2 Information Needed for Determination of Withdrawal Periods or Milk Discard Times; 3.3 Factors for Consideration in Conducting a Marker Residue Depletion Study; References; Acknowledgments; 4 Establishing Maximum Residue Limits in Europe; 4.1 Introduction; 4.2 Procedure for the Establishment of MRLs; 4.3 Scientific Evaluation 4.4 Extrapolation of MRLs4.5 Prohibited Drugs; 4.6 EU Policy on Minor Use and Minor Species; 4.7 EU Policy and Legislation on Feed Additives; 4.8 Off-Label Use; References; Acknowledgments; 5 Methods to Derive Withdrawal Periods in the European Union; 5.1 Introduction; 5.2 Withdrawal Periods for Meat; 5.3 Statistical Method; 5.4 Alternative Approach: Decision Rule; 5.5 Withdrawal Periods for Milk; 5.6 Withdrawal Periods for Eggs; 5.7 Withdrawal Periods for Honey; 5.8 Extrapolation of Withdrawal Periods; References; 6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 6.1 Introduction6.2 Applications of Population Modeling to Preslaughter Withdrawal Times; 6.3 Covariate Analysis; 6.4 Benefits to Population-Based Modeling Techniques; 6.5 Limitations of Population-Based Modeling Techniques; 6.6 Future Applications; 6.7 Conclusions; References; 7 Physiologically Based Pharmacokinetic Modeling; 7.1 Introduction; 7.2 Model Development and Validation; 7.3 PBPK Applied to Prediction of Drug Residues; 7.4 Conclusions; References; 8 Residue Avoidance in Beef Cattle Production Systems; 8.1 Introduction; 8.2 Beef Cattle Production Systems 8.3 Use of Anti-infective Agents in Beef Cattle Production8.4 Approaches to Minimize the Need for Antimicrobial Drugs; 8.5 Approaches to Minimize the Need for Parasiticides; 8.6 Approaches to Minimize Residues (Residue Avoidance); 8.7 Quality Assurance Programs; 8.8 The Future: Antimicrobial Regulation and the Market for "Antimicrobial-Free" Beef Products; References; 9 Residue Avoidance in Dairy Cattle Production Systems; 9.1 Prophylactic Use of Drugs in Dairy Cattle; 9.2 Therapeutic Use of Drugs in Dairy Cattle; 9.3 Prevalence of Drug Residues; 9.4 Minimizing Residues in Meat and Milk Summary Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. Focuses attention on drug and chemical residues in edible animal products Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals Details major drug classes used in food animal production and their residue risks Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Bibliography Includes bibliographical references and index Notes Print version record and CIP data provided by publisher Subject Food animals -- Feeding and feeds -- Contamination Food animals -- Nutrition Veterinary drug residues. Animal nutrition. TECHNOLOGY & ENGINEERING -- Agriculture -- Animal Husbandry. Animal nutrition Food animals -- Nutrition Veterinary drug residues Form Electronic book Author Baynes, Ronald, editor Riviere, J. Edmond (Jim Edmond), editor. LC no. 2014016529 ISBN 9781118872826 1118872827 9781118872802 1118872800 9781118872819 1118872819 0470247525 9780470247525 9781322078328 1322078327

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