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Book Cover
Author Li, Xiaokun, author.

Title Fibroblast growth factors / Xiaokun Li
Published London : Academic Press ; Beijing L Higher Education Press, [2018]


Description 1 online resource (xii, 571 pages)
Contents Front Cover; Fibroblast Growth Factors; Fibroblast Growth Factors; Copyright; Contents; Preface; Preface; 1 -- Engineered Growth Factor; Engineered Growth Factors and Cutaneous WoundHealing: Success and Possible Questions in the Past 10 Years; 1. Introduction; 2. Is There a Need for Exogenous Application of Growth Factors in Acute or Chronic Wounds?; 3. Have Growth Factors Altered Clinical Practice in the Past and Will They Alter It in the Future?; 4. Do We Need a Special Delivery System for the Growth Factors in Local Wound Healing?
5. Is It Safe to Use Growth Factors to Promote Wound Healing?6. Have All Problems Involved in Wound Healing Been Solved With Growth Factor Application?; 7. Can Perfect Wound Healing Be Achieved in Wounds Treated With Growth Factors?; 8. How Great a Change in Healing Events Would Require a Growth Factor to Become Clinically Important?; 9. What Needs to Be Done to Include Growth Factors in Clinical Practice Within the Next 5-10Years?; References; 2 -- FGFs in Injury Repair and Regeneration
Regulation of Autophagy and Ubiquitinated ProteinAccumulation by bFGF Promotes FunctionalRecovery and Neural Protection in a Rat Model of Spinal Cord Injury1. Introduction; 2. Materials and Methods; 2.1 Reagents and Antibodies; 2.2 Cell Culture; 2.3 Procedure for Investigating an Animal Model of Spinal Cord Injury; 2.4 Locomotion Recovery Assessment; 2.5 Hematoxylin-Eosin Staining and Nissl Staining; 2.6 Western Blot Analysis; 2.7 Immunofluorescence Staining; 2.8 Statistical Analysis; 3. Results; 3.1 bFGF Decreases Motor Neuron Loss and Improves Functional Recovery of SCI In Vivo
3.2 The Protective Effect of bFGF Is Related to Inhibited Autophagy in the SCI Model Mice3.3 Activation of PI3K/Akt/mTOR Signaling Pathways Is Involved in the Role of bFGF in SCI Recovery; 3.4 bFGF Improves Recovery After SCI by Autophagic Clearance of Ubiquitinated Protein Accumulation; 3.5 Combination With the Autophagy Sensitizer Rapamycin Partially Abolishes the Protective Effect of bFGF in SCI Model Rats; 3.6 Exogenous bFGF Protects PC-12 Cells by Inhibition of Excessive Autophagy In Vitro; 4. Discussion; The Antiscar Effects of bFGF on Wound RepairIn Vitro and In Vivo; 1. Introduction
2. Materials and Methods2.1 Ethics Statement; 2.2 Animal Model; 2.3 Histological Examination and Immunohistochemistry Staining; 2.4 Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick-End Labeling Staining; 2.5 Collagen I and Collagen III Quantification; 2.6 Western Blot; 2.7 Fibroblasts Culture; 2.8 Quantitative Real-Time PCR; 2.9 Statistical Analysis; 3. Results; 3.1 bFGF Accelerates Acute Wound Closure in the Rat-Incised Injury Model; 3.2 bFGF Alleviates the Scar Formation in the Rabbit Ear Model; 3.3 Effect of bFGF on Collagen I and Collagen III Synthesis
Summary Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on September 04, 2018)
Subject Fibroblast growth factors.
Receptors, Fibroblast Growth Factor
Fibroblast Growth Factor 2
Fibroblast Growth Factors
SOCIAL SCIENCE -- Anthropology -- Physical.
Fibroblast growth factors
Form Electronic book
ISBN 9780128161432