| Description |
1 online resource (ix, 233 pages) : illustrations |
| Series |
Novartis Foundation symposium ; 291 |
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Novartis Foundation symposium ; 291
|
| Contents |
1962-2007: a cell stress odyssey / J. Haak and K.C. Kregel -- The chaperone function: meanings and myths / P.A. Lund and R.J. Ellis -- Systems biology of molecular chaperone networks / P. Csermely [and others] -- Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10 / R.S. Gupta [and others] -- Cell surface molecular chaperones as endogenous modulators of the innate immune response / M. Triantafilou [and others] -- Cell stress proteins in extracellular fluids: friend or foe? / A.G. Pockley and G. Multhoff -- HSP60 speaks to the immune system in many voices / F.J. Quintana and I.R. Cohen -- Cell stress proteins: novel immunotherapeutics / S.K. Calderwood [and others] -- General discussion -- Cell stress proteins as modulators of bacteria--host interactions / B. Henderson -- Chaperonin 60 and macrophage activation / A.R. Coates, A. Cehovin and Y. Hu -- Hsp70: a chaperokine / A. Asea -- Extracellular functions of thioredoxin / H. Nakamura -- HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function / C.L. Miller-Graziano [and others] -- BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis / G.S. Panayi and V.M. Corrigall -- Final discussion |
| Summary |
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila . This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the 'molecular chaperone' concept as a general cellular function to control the process of correct protein folding, a large number of molecu |
| Analysis |
Biology |
|
Extracellular molecular chaperones |
| Notes |
"Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5-7 June 2007"--Page v |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
English |
|
Print version record |
| Subject |
Extracellular matrix proteins -- Congresses.
|
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Molecular chaperones -- Congresses.
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Extracellular Matrix Proteins.
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Molecular Chaperones.
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| Genre/Form |
Conference papers and proceedings.
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Conference papers and proceedings.
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| Form |
Electronic book
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| Author |
Chadwick, Derek.
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|
Goode, Jamie.
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Novartis Foundation.
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| ISBN |
0470754028 |
|
0470754036 |
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9780470754023 |
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9780470754030 |
|
(hbk.) |
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(hbk.) |
|
