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Book Cover
Author Golberg, Leon, author.

Title Hazard assessment of ethylene oxide / author, Leon Golberg
Published Boca Raton, FL : CRC Press, 2018


Description 1 online resource
Series CRC revivals
CRC revivals.
Contents Cover Page; Title Page; Copyright Page; Foreword; Preface; Acknowledgments; The Editor; Table of Contents; Chapter 1 Introduction; Chapter 2 Chemical and Physical Properties; I. Physical Properties; II. Structure; III. Specifications of EO; IV. Chemical Reactivity of EO; V. Reactivity of EO with Biological Nucleophiles; VI. Reactivity of EO with Hemoglobin; A. Endogenous Formation of EO; Chapter 3 Metabolism and Pharmacokinetics; Chapter 4 Acute, Subchronic, and Chronic Effects; I. Effects of Exposure to EO Vapor: Relevance for Risk Assessment; II. Analysis of Available Data
Chapter 5 Neuropharmacologic and Neurotoxic EffectsI. Introduction; II. Observations; A. Acute Exposure of Animals; B. Repeated Exposure of Animals; C. Acute Exposure of Humans; D. Repeated Exposure of Humans; E. Conclusions; Chapter 6 Reproductive and Teratogenic Effects; I. Introduction; II. Reproduction Studies; A. Animal Studies; B. Human Studies; C. Teratogenicity Studies; D. The NIOSH Study; Chapter 7 Mutagenicity Studies รข#x80;#x94; Genotoxic Effects of Ethylene Oxide in Experimental Models; I. Introduction; II. Nonmammalian Test Systems; III. Mammalian Test Systems
A. Unscheduled DNA SynthesisB. Cytogenetics: SCES; C. Micronucleus Test; D. Cytogenetics: Chromosomal Aberrations; E. Dominant Lethal Assay; F. Heritable Translocation Test; G. Sperm Motility and Morphology; IV. Specific-Locus Test; V. Risk Estimation Methods; A. Alkylation of Proteins and DNA; B. Mutagenesis Data Evaluation; Chapter 8 Carcinogenicity Studies; I. INTRODUCTION; II. Indirect Evidence for EO Carcinogenicity; III. Direct (Noninhalation) Studies of EO Carcinogenic Potential; IV. Intragastric Administration of EO; V. First Inhalation Carcinogenicity Study
VI. Second Inhalation StudyVII. Third Inhalation Study; VIII. Evaluation and Conclusions; A. Local Sarcomas and Gastric Lesions; B Tumors Associated With EO Irritancy; C. Tumors of the Forestomach; D. Subcutaneous Sarcomas; IX. Hyperplasia Associated With EO Irritancy or Possible Infection; A. Nasal Metaplasia; B. Adrenal Cortical Hyperplasia; X. INHALATION STUDIES; Chapter 9 Industrial Hygiene Aspects; I. INTRODUCTION; II. PERSONAL MONITORING; IV. AREA SAMPLING; V. EO Production and Use; VI. PRODUCER/ETHOXYLATOR INDUSTRIES; A. Control Measures; VII. Health Care Industry; A. Control Measures
Chapter 10 Epidemiologic StudiesI. INTRODUCTION; II. CARCINOGENICITY; III. DISCUSSION; IV. Other Health Effects; A. Lymphocytosis; B. Reproductive Effects; C. Cardiovascular Diseases; V. CYTOGENETIC STUDIES; A. Chromosomal Aberrations; B. SCEs; C. Reversibility of Cytogenetic Changes; D. SCEs: a Health Effect of EO?; Chapter 11 Hazard Assessment; I. Introduction; II. Use of Mathematical Models for Quantitative Risk Assessment; A. Animal Exposure Regimens and Worker Experience; B. Choice of a Model(s); III. Radequivalence: An Approach to Risk Assessment; IV. A Biological Perspective on EO
Summary "Hazard assessment of EO has involved consideration of the chemical composition, characteristics, and reactivity of this material. Teratogenic effects of EO are only seen under extreme conditions that render the result questionable. Reproductive effects or minor severity occur only at high levels of exposer. Epidemiological and other studies of occupational exposure to EO in men and women have revealed no substantial evidence of potential to produce cancer in the work place."--Provided by publisher
Bibliography Includes bibliographical references and index
Notes Vendor-supplied metadata
Subject Ethylene oxide -- Toxicology
Ethylene oxide -- Physiological effect
MEDICAL -- Pharmacology.
Ethylene oxide -- Physiological effect
Ethylene oxide -- Toxicology
Form Electronic book
ISBN 9781351072823