| Description |
1 online resource (xii, 300 pages) |
| Series |
Clinical aspects and laboratory determination of biomarkers series ; vol. 1 |
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Clinical aspects and laboratory determination of biomarkers series ; v. 1.
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| Contents |
880-01 Front Cover; Alcohol and Its Biomarkers; Copyright Page; Contents; Preface; 1 Alcohol; 1.1 Introduction; 1.2 Alcohol Consumption: Historical Perspective; 1.3 Alcohol Content of Various Alcoholic Beverages; 1.4 Guidelines for Alcohol Consumption; 1.5 Benefits of Drinking in Moderation; 1.5.1 Moderate Alcohol Consumption and Reduced Risk of Cardiovascular Disease; 1.5.2 Is Red Wine More Effective than other Alcoholic Beverages for Protecting the Heart?; 1.5.3 Moderate Consumption of Alcohol and Reduced Risk of Stroke |
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880-01/(S 5.6. Conclusions -- References -- ch. 6 Mean Corpuscular Volume and Carbohydrate-Deficient Transferrin as Alcohol Biomarkers -- 6.1. Introduction -- 6.2. Mean Corpuscular Volume as Alcohol Biomarker -- 6.2.1. Mechanism of Increased MCV in Alcoholics -- 6.2.2. Other Causes of Macrocytosis -- 6.3. Carbohydrate-Deficient Transferrin -- 6.3.1. Mechanism of Formation of CDT -- 6.3.2. Cutoff Values, Sensitivity, and Specificity of CDT -- 6.3.3. CDT and GGT as Combined Alcohol Biomarker -- 6.3.4. Application of CDT -- 6.3.5. Limitations of CDT as Alcohol Biomarker -- 6.4. Laboratory Determination of CDT -- 6.5. Conclusions -- References -- ch. 7 β-Hexosaminidase, Acetaldehyde-Protein Adducts, and Dolichol as Alcohol Biomarkers -- 7.1. Introduction -- 7.2. β-Hexosaminidase Isoforms -- 7.3. β-Hexosaminidase as Alcohol Biomarker -- 7.3.1. Pathophysiological Conditions that Cause Elevated Levels of β-Hexosaminidase -- 7.4. Laboratory Methods for Measuring β-Hexosaminidase -- 7.5. Acetaldehyde---Protein Adducts as Alcohol Biomarkers -- 7.5.1. Acetaldehyde---Hemoglobin Adducts -- 7.5.2. Acetaldehyde---Erythrocyte Protein Adducts -- 7.5.3. IgA Antibody Against Acetaldehyde-Modified Bovine Serum Albumin -- 7.6. Dolichol as Alcohol Biomarker -- 7.7. Conclusions -- References -- ch. 8 Direct Alcohol Biomarkers Ethyl Glucuronide, Ethyl Sulfate, Fatty Acid Ethyl Esters, and Phosphatidylethanol -- 8.1. Introduction -- 8.2. Ethyl Glucuronide and Ethyl Sulfate -- 8.3. Ethyl Glucuronide and Ethyl Sulfate as Alcohol Biomarkers -- 8.3.1. Ethyl Glucuronide and Ethyl Sulfate Observed Due to Incidental Exposure to Alcohol -- 8.3.2. Ethyl Glucuronide and Ethyl Sulfate Cutoff Concentrations in Urine -- 8.3.3. Ethyl Glucuronide and Ethyl Sulfate Cutoff Concentrations in Hair, Meconium, and other Matrices -- 8.3.4. False-Positive/False-Negative Results with Ethyl Glucuronide -- 8.3.5. Application of Ethyl Glucuronide and Ethyl Sulfate as Alcohol Biomarkers -- 8.3.6. Laboratory Methods for Determination of Ethyl Glucuronide and Ethyl Sulfate -- 8.4. Fatty Acid Ethyl Esters as Alcohol Biomarkers -- 8.4.1. Fatty Acid Ethyl Esters in Hair -- 8.4.2. Fatty Acid Ethyl Esters in Meconium -- 8.4.3. Laboratory Analysis of Fatty Acid Ethyl Esters -- 8.5. Phosphatidylethanol as Alcohol Biomarker -- 8.5.1. Cutoff Concentration of Phosphatidylethanol -- 8.5.2. Laboratory Analysis of Phosphatidylethanol -- 8.6. Sensitivity and Specificity of Direct Alcohol Biomarkers -- 8.7. Conclusions -- References -- ch. 9 Less Commonly Used Alcohol Biomarkers and Proteomics in Alcohol Biomarker Discovery -- 9.1. Introduction -- 9.2. Total Sialic Acid in Serum as Alcohol Biomarker -- 9.2.1. Other Causes of Elevated Plasma Sialic Acid Concentrations -- 9.2.2. Laboratory Determination of Total Sialic Acid -- 9.3. Sialic Acid Index of Apolipoprotein J as Alcohol Biomarker -- 9.3.1. Laboratory Methods for the Determination of the Sialic Acid Index of Plasma Apolipoprotein J -- 9.4. 5-Hydroxytryptophol as Alcohol Biomarker -- 9.4.1. Laboratory Methods for Determining 5-HTOL and 5-HIAA -- 9.5. Other Alcohol Biomarkers -- 9.6. Proteomics in Alcohol Biomarker Discovery -- 9.6.1. Specific Proteins Identified as Alcohol Biomarkers Using the Proteomics Approach -- 9.7. Conclusions -- References -- ch. 10 Genetic Markers of Alcohol Use Disorder -- 10.1. Introduction -- 10.2. Heredity, Environment, and Alcohol Use Disorder -- 10.2.1. Effect of Nongenetic Factors on the Development of Alcohol Use Disorder -- 10.3. Genes and Alcohol Use Disorder: An Overview -- 10.4. Polymorphisms in Genes Encoding Alcohol Dehydrogenase and Aldehyde Dehydrogenase -- 10.4.1. Polymorphisms that Protect from Alcohol Use Disorder -- 10.4.2. Polymorphisms that may Increase the Risk of Alcohol Use Disorder -- 10.5. Neurobiological Basis of Alcohol Use Disorder -- 10.6. Polymorphisms of Genes in Dopamine Pathway and Alcohol Use Disorder -- 10.6.1. Dopamine Receptors -- 10.6.2. Dopamine Transporters and Dopamine-Metabolizing Enzymes -- 10.6.3. Monoamine Oxidase -- 10.6.4. Catechol-O-Methyltransferase -- 10.7. Polymorphisms of Genes in the Serotonin Pathway and Alcohol Use Disorder -- 10.8. Polymorphisms of Genes in the Gaba Pathway and Alcohol Use Disorder -- 10.9. Polymorphisms of Genes Encoding Cholinergic Receptors and Alcohol Use Disorder -- 10.10. Polymorphisms of Genes in the Glutamate Pathway and Alcohol Use Disorder -- 10.11. Polymorphisms of Genes Encoding Opioid Receptors and Alcohol Use Disorder -- 10.12. Polymorphisms of Genes Encoding Cannabinoid Receptors and Alcohol Use Disorder -- 10.13. Adenylyl Cyclase and Alcohol Use Disorder -- 10.14. Neuropeptide Y and Alcohol Use Disorder |
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1.5.4 Moderate Consumption of Alcohol and Reduced Risk of Developing Metabolic Syndrome and Type 2 Diabetes1.5.5 Moderate Alcohol Consumption and Reduced Risk of Dementia/Alzheimer's Disease; 1.5.6 Association between Moderate Alcohol Consumption and Reduced Cancer Risk; 1.5.7 Can Moderate Alcohol Consumption Prolong Life?; 1.5.8 Moderate Alcohol Consumption and Reduced Risk of Arthritis; 1.5.9 Moderate Alcohol Consumption and Reduced Chance of Getting the Common Cold; 1.6 Adverse Heath Effects Related to Alcohol Dependence |
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1.6.1 Liver Diseases and Cirrhosis of the Liver Associated with Alcohol Abuse1.6.2 Alcohol Abuse and Neurological Damage; 1.6.3 Alcohol Abuse and Increased Risk of Cardiovascular Disease and Stroke; 1.6.4 Alcohol Abuse and Damage to the Immune System; 1.6.5 Alcohol Abuse and Damage to the Endocrine System and Bone; 1.6.6 Alcohol Abuse Increases the Risk of Certain Cancers; 1.6.7 Fetal Alcohol Syndrome; 1.6.8 Alcohol Abuse and Reduced Life Span; 1.6.9 Alcohol Abuse and Violent Behavior/Homicide; 1.6.10 Alcohol Poisoning; 1.7 Blood Alcohol Level |
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1.7.1 Alcohol Odor on Breath and Endogenous Alcohol Production1.8 Conclusions; References; 2 Genetic Aspects of Alcohol Metabolism and Drinking Behavior; 2.1 Introduction; 2.2 Alcohol Absorption: Effect of Food; 2.3 First-Pass Metabolism of Alcohol; 2.4 Alcohol Metabolism; 2.4.1 Non-Oxidative Pathways of Alcohol Metabolism; 2.4.2 Factors Affecting Alcohol Metabolism; 2.5 Genes Encoding Alcohol Dehydrogenase; 2.5.1 Polymorphism of Alcohol Dehydrogenase Genes; 2.6 Genes Encoding Aldehyde Dehydrogenase |
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2.6.1 Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Genes that Protect Against the Development of Alcoh ... 2.6.2 Polymorphism of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Genes that may Increase the Risk of Developing Alcoh ... ; 2.7 Polymorphism of the CYP2E1 Gene; 2.8 Conclusions; References; 3 Measurement of Alcohol Levels in Body Fluids and Transdermal Alcohol Sensors; 3.1 Introduction; 3.2 Breath Alcohol Determination; 3.2.1 Chemical Principle of Breath Alcohol Analyzers; 3.2.2 Effect of Breathing Pattern on Breath Alcohol Test Results |
| Summary |
Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuse |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Vendor-supplied metadata |
| Subject |
Alcoholism -- Genetic aspects
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Biochemical markers.
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Ethanol -- pharmacology
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Biomarkers
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Alcoholism -- genetics
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Alcoholism -- Genetic aspects
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Biochemical markers
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| Form |
Electronic book
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| ISBN |
9780128004098 |
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0128004096 |
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0128003391 |
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9780128003398 |
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