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Title Erythropoietin and the nervous system : novel therapeutic options for neuroprotection / edited by Ahmet Höke
Edition 1st ed
Published New York, NY : Springer, ©2006


Description 1 online resource (223 pages) : illustrations
Contents History and biology of erythropoietin in hematopoietic and non-neural tissues / Giorgia Melli, Sanjay C. Keswani and Ahmet Hoke -- Expression of erythropoietin and its receptor in the central nervous system / Hugo Marti and Christian Bauer -- Erythropoietin and neuroprotection in the central nervous system : intracellular signaling pathways / Murat Digicaylioglu -- Regulation of erythropoietin expression in the nervous system : the hypoxia inducible factor / Juan C, Chavez and JoAnn M. Gensert -- Erythropoietin neuroprotection in the term and preterm infant : safety and efficacy / Eric J. Demers and Sandra E, Juul -- Erythropoietin for the treatment of acute ischemic stroke : preclinical rationale / Michael J. Renzi, Linda K, Jollijfe, Francis X. Farrell and Kenneth J, Rhodes -- Erythropoietin neuroprotection in the retina / Gundula Rohde, Mathias Bdhr and Jochen H. Weishaupt -- Erythropoietin for treatment of human brain disease : experience from proof-of-concept trials / Hannelore Ehrenreich and Anna-Leena Siren -- Erythropoietin in spinal cord injury / Michael Brines and Anthony Cerami -- Erythropoietin and neuroprotection in the peripheral nervous system : in vivo studies / W. M, Campana -- An endogenous pathway preventing axonal degeneration mediated by Schwann cell : derived erythropoietin / Sanjay C. Keswani and Ahmet Hoke -- Role of erythropoietin in inflammatory pathologies of the CNS / P. Ghezzi, P. Bigini, M, Mengozzi -- Development of non-erythropoietic erythropoietin variants for neuroprotection / Lars Torup and Marcel Leist
Summary Erythropoietin and the Nervous System is the first book of its kind to bring together researchers from many different disciplines of neuroscience to present a current state-of-the-art review of multiple aspects of erythropoietin research as it relates to the nervous system. Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with the relatively safety profile of this FDA-approved drug makes it an ideal candidate to take into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This book should stimulate new research on erythropoietin and the nervous system and bring new investigators to the field. It will benefit scientists and clinicians interested in neuroprotection in the broadest sense
Analysis geneeskunde
public health
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references
Notes Print version record
In Springer e-books
Subject Erythropoietin -- Physiological aspects
Neuroprotective agents.
Erythropoietin -- therapeutic use
Nervous System Diseases -- drug therapy
Erythropoietin -- physiology
Nervous System Diseases -- prevention & control
Neuroprotective Agents
MEDICAL -- Neuroscience.
PSYCHOLOGY -- Neuropsychology.
Erythropoietin -- therapeutic use.
Nervous System Diseases -- drug therapy.
Erythropoietin -- physiology.
Nervous System Diseases -- prevention & control.
Neuroprotective Agents.
Erythropoietin -- Physiological aspects.
Nervous system -- Surgery
Form Electronic book
Author Höke, Ahmet
ISBN 9780387300115