Title EGFR signaling networks in cancer therapy / edited by John D. Haley, William John Gullick

Published New York : Humana Press, ©2008

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Description 1 online resource (xi, 393 pages) : illustrations Series Cancer drug discovery and development Cancer drug discovery and development. Contents Section I: EGFR signaling networks -- Section II: EGFR in tumorigenesis and EGFR tyrosine kinase inhibitors in cancer therapy Summary The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information Bibliography Includes bibliographical references and index Notes English Print version record Subject Cancer -- Treatment. Cancer -- Chemotherapy. ErbB Receptors -- antagonists & inhibitors ErbB Receptors -- metabolism Signal Transduction -- drug effects Neoplasms -- drug therapy Neoplasms -- metabolism MEDICAL -- Oncology. HEALTH & FITNESS -- Diseases -- Cancer. Neoplasms -- drug therapy. Neoplasms -- metabolism. Receptor, Epidermal Growth Factor -- antagonists & inhibitors. Receptor, Epidermal Growth Factor -- metabolism. Signal Transduction -- drug effects. Cancer -- Treatment. Cancer -- Chemotherapy. Cancer -- Chemotherapy Cancer -- Treatment Form Electronic book Author Haley, John D. Gullick, William John. LC no. 2008923173 ISBN 9781597453561 1597453560 1588299481 9781588299482 1282036335 9781282036338 9786612036330 6612036338

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