Limit search to available items
Book Cover

Title EGFR signaling networks in cancer therapy / edited by John D. Haley, William John Gullick
Published New York : Humana Press, ©2008


Description 1 online resource (xi, 393 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Section I: EGFR signaling networks -- Section II: EGFR in tumorigenesis and EGFR tyrosine kinase inhibitors in cancer therapy
Summary The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Cancer -- Treatment.
Cancer -- Chemotherapy.
ErbB Receptors -- antagonists & inhibitors
ErbB Receptors -- metabolism
Signal Transduction -- drug effects
Neoplasms -- drug therapy
Neoplasms -- metabolism
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Neoplasms -- drug therapy.
Neoplasms -- metabolism.
Receptor, Epidermal Growth Factor -- antagonists & inhibitors.
Receptor, Epidermal Growth Factor -- metabolism.
Signal Transduction -- drug effects.
Cancer -- Treatment.
Cancer -- Chemotherapy.
Cancer -- Chemotherapy.
Cancer -- Treatment.
Form Electronic book
Author Haley, John D.
Gullick, William John.
ISBN 9781597453561