Limit search to available items
Book Cover

Title Tight junctions in inflammation and cancer / Ajaz A. Bhat, Mohammad Haris, Muzafar A. Macha, Punita Dhawan, editors
Published Singapore : Springer, 2023


Description 1 online resource (290 pages) : illustrations (color)
Contents Chapter 1. Inflammation and Cancer: Role of Tight Junctions -- Chapter 2. Regulation of tight junction by cadherin adhesion and its implication in inflammation and cancer -- Chapter 3. Tight junctions, epithelial-mesenchymal transition and cancer metastasis -- Chapter 4. Imaging techniques to study tight junctions -- Chapter 5. Tight junction proteins as emerging drug targets: Expanding the horizons from inflammation to cancer -- Chapter 6. Tight Junctions and signaling pathways in cancer -- Chapter 7. Molecular architecture and function of tight junctions -- Chapter 8. The role of tight junction proteins in cancer
Summary This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists
Notes Print version record
Subject Endothelium -- Tumors
Epithelium -- Tumors.
Tight junctions (Cell biology)
Junctional complexes (Epithelium)
Epithelium -- Tumors.
Junctional complexes (Epithelium)
Tight junctions (Cell biology)
Form Electronic book
Author Bhat, Ajaz A., editor.
Haris, Mohammad, editor
Macha, Muzafar Ahmad, 1981- editor.
Dhawan, Punita, editor
ISBN 9789819924158