Description |
1 online resource : illustrations (some color) |
Contents |
Part 1. Cellular responses to ER stress -- Biology of the Endoplasmic Reticulum / Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis and Afshin Samali -- A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Response / Jared Q Gerlach, Shashank Sharma, Kirk J Leister and Lokesh Joshi -- ER Stress Signaling Pathways in Cell Survival and Death / Tom Verfaillie, Richard Jäger, Afshin Samali and Patrizia Agostinis -- Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection / Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo and Cristina Fasolato -- ER Stress and UPR Through Dysregulated ER Ca2+ Homeostasis and Signaling / Tim Vervliet, Santeri Kiviluoto and Geert Bultynck -- Regulation of ER Stress Responses by microRNAs / Danielle E. Read, Ananya Gupta, Karen Cawley and Sanjeev Gupta -- ER Stress As Modulator of Autophagy Pathways / María Salazar, Sonia Hernández-Tiedra, Mar Lorente and Guillermo Velasco -- Physiological ER Stress: The Model of Insulin-Secreting Pancreatic b-Cells / Mohammed Bensellam, Patrick Gilon and Jean-Christophe Jonas |
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Part 2. ER stress in physiological & pathological conditions -- Pathological ER Stress in [beta] Cells / Fumihiko Urano and Bryan O'Sullivan-Murphy -- Endoplasmic Reticulum Stress and the Unfolded Protein Response in Lipid Metabolism and Obesity / Sana Basseri and Richard C. Austin -- ER Stress and Inflammation / Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko and Peter Vandenabeele -- ER Stress in Intestinal Inflammatory Disease / Michal F. Tomczak, Arthur Kaser and Richard S. Blumberg -- Role of ER Stress in Dysfunction of the Nervous System / Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson and Fumihiko Urano -- Endoplasmic Reticulum (ER) Stress in Amyotrophic Lateral Sclerosis (ALS) / Han-Jou Chen and Jackie de Belleroche -- Cardiovascular Disease and Endoplasmic Reticulum Stress / Jody Groenendyk and Marek Michalak -- Signaling the Unfolded Protein Response in cancer / Stéphanie Lhomond and Eric Chevet -- UPR Activation in Cancer Cells: A Double-Edged Sword / Ethel R. Pereira, Amanda M. Preston and Linda M. Hendershot -- Contribution of ER Stress to Immunogenic Cancer Cell Death / Abhishek D. Garg, Dmitri V. Krysko, Jakub Golab, Peter Vandenabeele and Patrizia Agostinis -- Current advances in ER stress intervention therapies / Laurence A. Booth, Nichola Cruickshanks, Yong Tang, M. Danielle Bareford and Hossein A. Hamed, et al |
Summary |
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as âER stressâ. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases |
Analysis |
geneeskunde |
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medicine |
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celbiologie |
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cellular biology |
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biomedische wetenschappen |
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biomedicine |
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immunologie |
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immunology |
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celfysiologie |
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cell physiology |
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apoptose |
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apoptosis |
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Medicine (General) |
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Geneeskunde (algemeen) |
Notes |
English |
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Print version record |
Subject |
Endoplasmic reticulum -- Pathophysiology
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Cellular signal transduction.
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Endoplasmic Reticulum Stress
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Signal Transduction
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SCIENCE -- Life Sciences -- Cell Biology.
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Cellular signal transduction
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Form |
Electronic book
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Author |
Agostinis, Patrizia
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Afshin, Samali
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ISBN |
9789400743519 |
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9400743513 |
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9400792514 |
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9789400792517 |
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