Title Silica nanoparticles as drug delivery system for immunomodulator GMDP / E.V. Parfenyuk [and others]

Published New York, N.Y. : ASME ; [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : Momentum Press, 2012

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Description 1 online resource (x, 69 pages) : illustrations, digital file Series Biomedical and nanomedical technologies Biomedical & nanomedical technologies. Contents Introduction 1. Drug delivery nanosystems as a promising area of modern chemistry and medicine. Silica nanoparticles as potential drug carriers 2. Syntheses of mesoporous silica materials -- 2.1 Syntheses of unmodified silica materials -- 2.2 Synthesis of modified silica materials 3. Characterization of silica materials as potential carriers for GMDP. -- 3.1 Characterization of silica materials via FTIR spectroscopy -- 3.2 Characterization of silica materials via nitrogen adsorption-desorption measurements -- 3.3 Particle size of silica materials -- 3.4 Characterization of silica materials via small angle x-ray scattering (SAXS) -- 3.5 Adsorption properties of silica materials -- 3.6 DSC study of composites of model protein with silica materials -- 3.7 Calorimetric study of adsorption of model protein on silica materials -- 3.8 Preparation of silica nanoparticle suspensions 4. Interaction of silica nanoparticles with immune system cells -- 4.1 Intensity of different silica nanoparticles uptake by immune cells -- 4.2 Influence of silica nanoparticles on parameters of functional activity of peritoneal macrophages 5. Peritoneal macrophages of women with endometriosis as a possible target for immunomodulatory drugs -- 5.1 Impairment of peritoneal macrophage function at endometriosis -- 5.2 Influence of glucosaminyl muramyldipeptide upon functional activity of peritoneal macrophages of women with endometriosis 6. Effectiveness of different types of silica nanoparticles as drug carriers for topical delivery of GMDP into peritoneal macrophages of women with endometriosis -- 6.1 Immobilization of GMDP on silica nanoparticles -- 6.2 Comparative study of the effects of free GMDP and GMD immobilized on silica nanoparticles on the functional state of peritoneal macrophages References Summary The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging its retention, half-life and effectiveness. Therefore, such "smart" nanodevices are able to change radically the practice of therapy for a variety of diseases and disorders. The purpose of this book is to present the recent research development of nanoparticulate delivery systems for immune modulating agent, glucosaminyl muramyldipeptides (N-acetylglucosaminyl-Nacetylmuramyl- L-alanyl-D-isoglutamine) or GMDP, which is the main component of bacterial wall with known target of action through NOD2 receptors, with an overlook to their applications for treatment of endometriosis, which often results in infertility. Silica-based nanoparticles have generated a significant amount of interest because of their inherent properties Analysis Mesoporous silica nanoparticles sol-gel synthesis surface functionalization glucosaminyl muramyldipeptide endometriosis drug delivery system drug immobilization blood lymphocytes peritoneal macrophages scavenger receptors functional activity of the immune cells Notes Title from PDF title page (viewed on September 27, 2012) Bibliography Includes bibliographical references (pages 59-69) Subject Drug delivery systems. Nanosilicon. Immunological adjuvants. Nanomedicine. Nanoparticles. Endometriosis -- Treatment Nanotechnology. Silicon. Adjuvants, Immunologic Drug Delivery Systems Endometriosis -- therapy Nanomedicine Nanoparticles Silicon Nanotechnology silicon. MEDICAL -- Pharmacology. Silicon Nanotechnology Drug delivery systems Endometriosis -- Treatment Immunological adjuvants Nanomedicine Nanoparticles Nanosilicon Form Electronic book Author Parfenyuk, E. V ISBN 9781606503959 1606503952 1606504215 9781606504215

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