Limit search to available items
Book Cover
Author Dalmau, Josep, 1953- author.

Title Autoimmune encephalitis and related disorders of the central nervous system / Josep Dalmau, Francesc Graus
Published Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2022


Description 1 online resource (unpaged) : color illustrations
Contents Importance, definitions, history, and classification of the autoimmune encephalitides -- General approach to diagnosis -- Pathogenesis and disease mechanisms in neuronal antibody-mediated encephalitis -- Intracellular antigens -- Cell surface antigens -- Limbic encephalitis -- Autoimmunity against proteins associated with voltage-gated potassium channels -- Anti-NMDA receptor encephalitis -- Seizures and autoantibodies against surface antigens -- Acute disseminated encephalomyelitis and myelin oligodendrocyte glycoprotein antibody-associated disease -- Neuromyelitis optica spectrum disorders and glial fibrillary acidic protein autoimmunity -- Autoimmune cerebellar ataxias -- Autoimmune brainstem encephalitis -- Autoimmunity against the inhibitory synapsis -- Anti-IgLON5 disease -- Autoimmune and inflammatory encephalopathies as complication of cancer -- Deconstructing Hashimoto encephalopathy -- CNS syndromes at the frontier of autoimmune encephalitis -- Autoimmune psychosis -- Psychiatric manifestations of autoimmune encephalitis -- Abnormal movements in neurological autoimmune disorders -- Sleep and autoimmunity -- Immunity, inflammation, and epilepsy -- Autoimmune dementia: a useful term? -- Frequently asked questions
Summary "About 20 years ago the group of diseases currently known as "autoimmune encephalitides" or "antibody-mediated encephalitides" was unknown and the field of "Autoimmune Neurology" inexistent. Since then, 18 autoimmune encephalitides and the corresponding syndromes have been described including 16 in which the antigens are expressed on the cell surface of neurons and two on the surface of glial cells.1-3 In many of these diseases several immunological triggers have been identified - usually tumors or viral infections -, and in some, a genetic susceptibility linked to distinct human leukocyte antigen (HLA) has been shown.1, 4 These findings along with the availability of specific diagnostic tests and clinical guidelines,5 have remarkably changed the diagnostic and treatment approach to patients with encephalitis of unclear etiology which until recently comprised 45-50% of all cases of encephalitis and now represent only 20-25% of all cases.6 Neurologic disorders once considered idiopathic, or ascribed to possible infections, or defined with descriptive terms, are now recognized as autoimmune diseases that may lead to psychosis, catatonia, abnormal movements, seizures, memory impairment, cognitive decline, dysautonomia, or spinal cord dysfunction. Due to the severity and duration of these symptoms, up to 50% of patients require and receive prolonged intensive care support that not long ago may have been considered futile.7, 8"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Description based on online resource; title from digital title page (viewed on April 25, 2022)
Subject Encephalitis -- Immunology
Encephalomyelitis -- Immunology
Encephalitis -- immunology
Encephalomyelitis -- immunology
Autoimmune Diseases of the Nervous System
Form Electronic book
Author Graus, Francesc, 1953- author.
LC no. 2021027939
ISBN 9781108696722