Title Enantioselective synthesis of [beta]-amino acids / edited by Eusebio Juaristi, Vadim A. Soloshonok

Edition 2nd ed Published Hoboken, N.J. : Wiley, ©2005

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Description 1 online resource (xx, 634 pages) : illustrations Contents ENANTIOSELECTIVE SYNTHESIS OF b-AMINO ACIDS; CONTENTS; Preface; Preface to the First Edition; Contributors; 1. Structural Types of Relevant b-Amino Acid Targets; 2. b-Amino Acids in Natural Products; 3. Preparation of Enantiopure b-Amino Acids by Homologation of a-Amino Acids; 4. Asymmetric Catalysis in Enantioselective Synthesis of b-Amino Acids; 5. Enantioselective Synthesis of Conformationally Constrained b-Amino Acids; 6. Catalytic Enantioselective Mannich Reactions; 7. Enantioselective Synthesis of b-Amino Acids via Stereoselective Hydrogenation of b-Aminoacrylic Acid Derivatives 8. Asymmetric Synthesis of b-Amino Acids by Enolate Additions to tert-Butanesulfinyl Imines9. Organocatalytic Approaches to Enantioenriched b-Amino Acids; 10. Asymmetric Synthesis of Cyclic b-Amino Acids via Cycloaddition Reactions; 11. Enantioselective Synthesis of Novel b-Amino Acids; 12. Asymmetric Synthesis of Phosphonic Analogs of b-Amino Acids; 13. Asymmetric Synthesis of a-Substituted-b-Amino Phosphonates and Phosphinates and b-Amino Sulfur Analogs; 14. Stereoselective Synthesis of Fluorine-Containing b-Amino Acids 15. Enantioselective Synthesis of b-Amino Acids via Conjugate Addition to a,b-Unsaturated Carbonyl Compounds16. Preparation of Enantiopure b-Amino Acids via Enantioselective Conjugate Addition; 17. Biocatalytic Entry to Enantiomerically Pure b-Amino Acids; 18. Stereoselective Synthesis of b-Amino Acids via Radical Reactions; 19. Recent Advances in Synthesis of a-Hydroxy-b-amino Acids and Their Use in SAR Studies of Taxane Anticancer Agents; 20. Synthesis of b-Amino Acids and Their Derivatives from b-Lactams: Update 21. Multiple-Component Condensation Methods for Preparation of Combinatorial Libraries of b-Amino Carbonyl Derivatives22. Using Constrained b-Amino Acid Residues to Control b-Peptide Shape and Function; 23. b(2)-Amino Acids with Proteinogenic Side Chains and Corresponding Peptides: Synthesis, Secondary Structure, and Biological Activity; Index Summary Covers all facets of the synthesis of ?-amino acidsAs evidenced by an exponential increase in the literature published on the subject, interest in ?-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others.This Second Edition of Enantioselective Synthesis of ?-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The b Analysis Organic Chemistry Bibliography Includes bibliographical references and index Notes Print version record Subject Beta lactam antibiotics -- Synthesis Amino acids -- Synthesis. Chiral drugs -- Synthesis Enantiomers -- Synthesis Stereoisomers. Amino Acids -- chemical synthesis Stereoisomerism beta-Lactams -- chemical synthesis MEDICAL -- Drug Guides. MEDICAL -- Pharmacology. MEDICAL -- Pharmacy. MEDICAL -- Nursing -- Pharmacology. Stereoisomers Amino acids -- Synthesis Beta lactam antibiotics -- Synthesis Chiral drugs -- Synthesis Enantiomers -- Synthesis Aminozuren. Synthese (chemie) Enantiomeren. Chiraliteit. Stereoselectiviteit. Genre/Form Electronic books Form Electronic book Author Juaristi, Eusebio. Soloshonok, V. A. LC no. 2004010498 ISBN 0471698474 9780471698470 9780471467380 0471467383 0471698482 9780471698487

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