| Description |
1 online resource (xiii, 497 pages) : illustrations (some color) |
| Series |
Methods in molecular medicine ; 37 |
|
Methods in molecular medicine ; 37.
|
| Contents |
Principles of membrane electroporation and transport of macromolecules / E. Neumann, S. Kakorin and K. Toensing-Instrumentation and electrodes for in vivo electroporation / G.A. Hofmann-Numerical modeling for in vivo electroporation / D. Semrov and D. Miklavcic-In vitro delivery of drugs and other molecules to cells / M.P. Rols [and others]-The basis of electrochemotherapy / L.M. Mir and S. Orlowski-Electrochemotherapy : Animal model work review / G. Sersa-Clinical trials for solid tumors using electrochemotherapy / R. Heller, R. Gilbert and M.J. Jaroszeski-In vitro and ex vivo gene delivery to cells by electroporation / S.W. Hui and L.H. Li-Delivery of genes in vivo using pulsed electric fields / M.J. Jaroszeski [and others]-Mechanism of transdermal drug delivery by electroporation / T.E. Vaughan and J.C. Weaver-Mechanistic studies of skin electroporation using biophysical methods / M.R. Prausnitz, U. Pliquett and R. Vanbever-Treatment of murine transplanted subcutaneous tumors using systemic drug administration / S. Orlowski and L.M. Mir-Electrochemotherapy of murine melanoma using intratumor drug administration / R. Heller, R. Gilbert and M.J. Jaroszeski-Treatment of a tumor model with ect using 4+4 electrode configuration / M. Cemazar-Treatment of multiple spontaneous breast tumors in mice using electrochemotherapy / S. Orlowski and L.M. Mir-Electroporation of muscle tissue in vivo / J. Gehl and L.M. Mir-Treatment of human pancreatic tumors xenografted in nude mice by chemotherapy combined with pulsed electric fields / S.B. Dev, G.A. Hofmann and G.S. Nanda-Distribution of bleomycin in a rat model / P. Engstrom, L.G. Salford and B.R. Persson-Treatment of rat bladder cancer with electrochemotherapy in vivo / Y. Kubota, T. Nakada and I. Sasagawa-Electrochemotherapy for the treatment of soft tissue sarcoma in a rat model / R. Gilbert, M.J. Jaroszeski and R. Heller-Treatment of spontaneous soft tissue sarcomas in cat / S. Orlowski and L.M. Mir-Treatment of rat glioma with electrochemotherapy / L.G. Salford, P. Engstrom and B.R. Persson-Treatment of liver malignancies with electrochemotherapy in a rat model / M.J. Jaroszeski, R. Gilbert and R. Heller-Treatment of liver tumors in rabbit / S. Orlowski and L.M. Mir-Electrically mediated reporter gene transfer into normal rat liver tissue / M.J. Jaroszeski [and others]-Reporter/functional gene transfer in rat brain / T. Nishi [and others]-In vivo gene electroporation in the mouse testis / T. Muramatsu-Ex vivo stromal cell electroporation of factor ix cdna for treatment of hemophilia b / A. Keating [and others]-In ovo gene electroporation into early chicken embryos / T. Muramatsu-Electrical impedance spectroscopy for rapid and noninvasive analysis of skin electroporation / U. Pliquett and M.R. Prausnitz-An in vitro system for measuring the transdermal voltage and molecular flux across the skin in real time / T. Chen, R. Langer and J.C. Weaver-Using surface electrodes to monitor the electric-pulse-induced permeabilization of porcine skin / S.A. Gallo, P.G. Johnson and S.W. Hui-Transdermal delivery using surface electrodes in porcine skin / P.G. Johnson, S.A. Gallo and S.W. Hui-Transdermal drug delivery by skin electroporation in the rat / R. Vanbever and V. Preat-In vivo skin-targeted gene delivery by pulsed electric fields / L. Zhang |
| Summary |
In Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery, leading experts comprehensively review all aspects of the delivery of therapeutic molecules to cells using electrical impulses-i.e., the extraordinarily promising new areas of electrogene therapy, electrochemotherapy, and transdermal drug delivery. Their survey ranges from outlines of the basic physical principles that govern cell permeabilization by pulsed electric fields, to descriptions of the current state-of-the-art in instrumentation and electrodes, to summaries of preclinical and clinical trial results. The authors focus on drug, gene, and transdermal delivery techniques, providing detailed examples of drug delivery using electric fields from a variety of pulse generators and electrodes. The protocols cover almost every variation in procedure and/or apparatus so that investigators can readily identify the method needed for their own work, or adapt one to their particular purposes. Comprehensive and authoritative, Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery provides entré to an immensely practical set of in vivo electroporation techniques, including electrogene therapy, electrochemotherapy, and transdermal drug delivery-techniques holding great promise for all those working toward better therapies for in cancer, metabolic diseases, and vaccination |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Principles of membrane electroporation and transport of macromolecules / E. Neumann, S. Kakorin and K. Toensing-Instrumentation and electrodes for in vivo electroporation / G.A. Hofmann-Numerical modeling for in vivo electroporation / D. Semrov and D. Miklavcic-In vitro delivery of drugs and other molecules to cells / M.P. Rols [and others]-The basis of electrochemotherapy / L.M. Mir and S. Orlowski-Electrochemotherapy : Animal model work review / G. Sersa-Clinical trials for solid tumors using electrochemotherapy / R. Heller, R. Gilbert and M.J. Jaroszeski-In vitro and ex vivo gene delivery to cells by electroporation / S.W. Hui and L.H. Li-Delivery of genes in vivo using pulsed electric fields / M.J. Jaroszeski [and others]-Mechanism of transdermal drug delivery by electroporation / T.E. Vaughan and J.C. Weaver-Mechanistic studies of skin electroporation using biophysical methods / M.R. Prausnitz, U. Pliquett and R. Vanbever-Treatment of murine transplanted subcutaneous tumors using systemic drug administration / S. Orlowski and L.M. Mir-Electrochemotherapy of murine melanoma using intratumor drug administration / R. Heller, R. Gilbert and M.J. Jaroszeski-Treatment of a tumor model with ect using 4+4 electrode configuration / M. Cemazar-Treatment of multiple spontaneous breast tumors in mice using electrochemotherapy / S. Orlowski and L.M. Mir-Electroporation of muscle tissue in vivo / J. Gehl and L.M. Mir-Treatment of human pancreatic tumors xenografted in nude mice by chemotherapy combined with pulsed electric fields / S.B. Dev, G.A. Hofmann and G.S. Nanda-Distribution of bleomycin in a rat model / P. Engstrom, L.G. Salford and B.R. Persson-Treatment of rat bladder cancer with electrochemotherapy in vivo / Y. Kubota, T. Nakada and I. Sasagawa-Electrochemotherapy for the treatment of soft tissue sarcoma in a rat model / R. Gilbert, M.J. Jaroszeski and R. Heller-Treatment of spontaneous soft tissue sarcomas in cat / S. Orlowski and L.M. Mir-Treatment of rat glioma with electrochemotherapy / L.G. Salford, P. Engstrom and B.R. Persson-Treatment of liver malignancies with electrochemotherapy in a rat model / M.J. Jaroszeski, R. Gilbert and R. Heller-Treatment of liver tumors in rabbit / S. Orlowski and L.M. Mir-Electrically mediated reporter gene transfer into normal rat liver tissue / M.J. Jaroszeski [and others]-Reporter/functional gene transfer in rat brain / T. Nishi [and others]-In vivo gene electroporation in the mouse testis / T. Muramatsu-Ex vivo stromal cell electroporation of factor ix cdna for treatment of hemophilia b / A. Keating [and others]-In ovo gene electroporation into early chicken embryos / T. Muramatsu-Electrical impedance spectroscopy for rapid and noninvasive analysis of skin electroporation / U. Pliquett and M.R. Prausnitz-An in vitro system for measuring the transdermal voltage and molecular flux across the skin in real time / T. Chen, R. Langer and J.C. Weaver-Using surface electrodes to monitor the electric-pulse-induced permeabilization of porcine skin / S.A. Gallo, P.G. Johnson and S.W. Hui-Transdermal delivery using surface electrodes in porcine skin / P.G. Johnson, S.A. Gallo and S.W. Hui-Transdermal drug delivery by skin electroporation in the rat / R. Vanbever and V. Preat-In vivo skin-targeted gene delivery by pulsed electric fields / L. Zhang |
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Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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English |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Electroporation.
|
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Transdermal medication.
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Bioelectrochemistry.
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Cancer -- Chemotherapy.
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Electrochemistry.
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Animals
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Electroporation
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Administration, Cutaneous
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Electrochemistry
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Neoplasms -- drug therapy
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MEDICAL -- Pharmacology.
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Electrochemistry
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Bioelectrochemistry
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Cancer -- Chemotherapy
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Electroporation
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Transdermal medication
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Wetenschappelijke technieken.
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| Genre/Form |
Laboratory manuals.
|
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Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Jaroszeski, Mark J.
|
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Heller, Richard, 1954-
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Gilbert, Richard, PhD.
|
| ISBN |
9781592590803 |
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0896036065 |
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9780896036062 |
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1592590802 |
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1280820705 |
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9781280820700 |
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9786610820702 |
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6610820708 |
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