Title Electrically assisted transdermal and topical drug delivery / Ajay K. Banga

Published London ; Bristol, PA : Taylor & Francis Group, ©1998

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Description 1 online resource (xi, 172 pages) : illustrations Contents Cover -- Title -- Copyright -- Contents -- Preface -- About the author -- 1 Percutaneous absorption and its enhancement -- 1.1 Introduction -- 1.2 Structure, enzymatic activity and immunology of the skin -- 1.3 Percutaneous absorption -- 1.4 Iontophoretic enhancement of percutaneous absorption -- 1.5 Other methods for enhancement of percutaneous absorption -- 2 Iontophoretic transdermal drug delivery -- 2.1 Introduction -- 2.2 Electrical properties of the skin -- 2.3 Pathways of iontophoretic drug delivery -- 2.4 Theoretical basis of iontophoresis -- 2.5 Factors affecting iontophoretic delivery -- 2.6 Electro-osmotic flow -- 2.7 Reverse iontophoresis -- 2.8 Case studies -- 3 In vitro experimental techniques for iontophoresis research in the laboratory -- 3.1 Introduction -- 3.2 Selection of skin or membrane -- 3.3 In vitro transdermal iontophoresis studies -- 3.4 pH control in iontophoresis research -- 3.5 Novel formulations for iontophoretic delivery -- 4 Clinical applications of iontophoresis devices for topical dermatological delivery -- 4.1 Introduction -- 4.2 Clinical applications of iontophoresis -- 4.3 Iontophoresis devices -- 4.4 Electrode design -- 4.5 Treatment protocols and formulations -- 5 Iontophoretic delivery of peptides -- 5.1 Introduction -- 5.2 Structural considerations of polypeptides relevant to iontophoretic delivery -- 5.3 Peptides as iontophoresis candidates -- 5.4 Protease inhibitors and permeation enhancers for iontophoretic delivery -- 5.5 Case studies -- 5.6 Iontophoretic delivery of insulin: fact or fiction? -- 6 Transdermal delivery by electroporation -- 6.1 Introduction -- 6.2 Electropermeabilization of the skin -- 6.3 Electroporation equipment -- 6.4 Factors affecting delivery by electroporation -- 6.5 Pulsatile delivery of drugs by electroporation -- 6.6 Skin toxicology of electroporation -- 6.7 Delivery of particulates into the skin -- 6.8 Electroporation for cancer chemotherapy -- 6.9 Commercial development of electroporation -- 7 Electrically assisted delivery of gene-based drugs to skin -- 7.1 Introduction -- 7.2 Delivery of oligonucleotides -- 7.3 Delivery of genes -- 7.4 DNA vaccines -- 8 Developmental issues and commercialization of wearable iontophoretic patches -- 8.1 Introduction -- 8.2 Human studies -- 8.3 Dose and bioavailability -- 8.4 Biological and safety issues -- 8.5 Skin damage and its measurement -- 8.6 Patch design and manufacture -- 8.7 Developmental and regulatory issues -- Bibliography -- Index Summary This volume provides coverage assisted transdermal and topical delivery by mechanisms of iontophoresis, electroosmosis and electroporation. Provides a wealth of theoretical and practical information not found in any other single source Bibliography Includes bibliographical references (pages 135-169) and index Notes English Print version record Subject Transdermal medication. Iontophoresis. Electro-osmosis. Electroporation. Administration, Cutaneous Electroporation Iontophoresis Electro-osmosis Electroporation Iontophoresis Transdermal medication Form Electronic book ISBN 9780203483985 0203483987 9780748406876 0748406875 1282778749 9781282778740 9786612778742 6612778741 1135793409 9781135793401 0429204620 9780429204623

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