| Description |
1 online resource |
| Contents |
Systemic corticosteroids for autoimmune/inflammatory disorders in children : introduction / Giuseppe Saggese and Francesco Vierucci -- Corticosteroids in the treatment of childhood rheumatic diseases : a historical review / Ross E. Petty -- Systemic corticosteroids for autoimmune/inflammatory disorders in children : clinical aspects / Pascal Pillet -- The molecular and cellular mechanisms responsible for the anti-inflammatory and immunosuppressive effects of glucocorticoids / Giruseppe Nocentini, Graziella Migliorati, and Carlo Riccardi -- The clinical pharmacology of past, present, and future glucocorticoids / Giuseppe Nocentini, Simona Ronchetti, Stefano Bruscoli, and Carlo Riccardi -- Corticosteroids in juvenile idiopathic arthritis / María M. Katsicas and Ricardo A.G. Russo -- Systemic corticosteroids in childhood vasculitides / Gas̆per Markelj and Tadej Avc̆in -- Corticosteroids in pediatric-onset SLE and other connective tissue diseases / Alexandre Belot -- Glucocorticoids in pediatric gastrointestinal disorders / Sara De Iudicibus, Stefano Martelossi, and Giuliana Decorti -- Corticosteroids in pediatric dermatology / Stefano Cambiaghi and Carlo Gelmetti -- Corticosteroids in pediatric endocrinology / Cosimo Giannini and Angelika Mohn -- Systemic corticosteroids in respiratory diseases in children / Chiara Caparelli, Claudia Calogero, and Enrico Lombardi -- Corticosteroids in paediatric nephrology / Kjell Tullus -- Corticosteroids in neonatology : postnatal corticosteroids in preterm infants with bronchopulmonary dysplasia / Silvia Perugi and Carlo Dani |
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Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Introduction; References; Corticosteroids in the Treatment of Childhood Rheumatic Diseases: A Historical Review; The Origins of Corticosteroid Therapy; Corticosteroids in the Treatment of Childhood Arthritis; Corticosteroids in Treatment of Connective Tissue Diseases of Childhood; Pursuit of Efficacy with Minimal Toxicity; Summary; References; Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Clinical Aspects; Introduction; Mechanisms of Action; Pharmacology |
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Conditions of Prescription and Main Indications (Table 2) How to Limit the Main Side Effects of GCs; Metabolic Complications; Osteoporosis; Growth-Retarding Effects; Infections; Psychiatric Disturbances; Conclusion; References; The Molecular and Cellular Mechanisms Responsible for the Anti-inflammatory and Immunosuppressive Effects of Glucocorticoids; Introduction; Molecular Mechanisms of Glucocorticoids; Genomic Effects; Upregulation of Gene Transcription; Downregulation of Gene Transcription; Downregulation of Gene Transcription by GR-Dependent Upregulation of Inhibitory Factors |
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Nongenomic Effects GC-Activated Anti-inflammatory and Immunosuppressive Pathways; Effects on T Lymphocytes; Effects on Regulatory T Cells; Effects on Effector T Cells; Effects on Thymocytes; Effects on the Cells of Innate Immunity; Conclusions; References; The Clinical Pharmacology of Past, Present, and Future Glucocorticoids; Introduction; Past, Present, and Future GCs; Old GCs; New Generation of Topical GCs; Selective GR Agonists; Long-Circulating Liposomal GCs and Other Reformulations of Old GCs; Intersubjective Variability in the Response to GCs; Genetic Resistance to GCs |
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Acquired Resistance to GCs GCs and Gender; Molecular Basis of GC Interactions; Synergism in the Treatment of Asthmatic Patients; Pharmacokinetic Interactions; Conclusions; References; Corticosteroids in Juvenile Idiopathic Arthritis; The Use of Corticosteroids in the Treatment of Juvenile Idiopathic Arthritis; Corticosteroids in the Different JIA Categories; Systemic JIA; Polyarticular JIA; Oligoarticular JIA; Juvenile Psoriatic Arthritis; Enthesitis-Related Arthritis; Corticosteroids in MAS; Corticosteroids in JIA-Related Uveitis; Intra-articular Corticosteroid Therapy in JIA |
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ConclusionsReferences; Systemic Corticosteroids in Childhood Vasculitides; Introduction; Henoch-Schönlein Purpura; Clinical Manifestations; Cutaneous Involvement; Arthritis; Gastrointestinal Manifestations; Renal Disease; Treatment; Prognosis; Kawasaki Disease; Clinical Manifestations; Treatment; Polyarteritis Nodosa; Treatment; Takayasu Arteritis; Treatment; ANCA-Associated Vasculitides; Treatment; Central Nervous System Vasculitis; Treatment; References; Corticosteroids in Pediatric-Onset SLE and Other Connective Tissue Diseases; Introduction |
| Summary |
This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids st |
| Analysis |
therapie |
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therapy |
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farmacologie |
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pharmacology |
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pediatrie |
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paediatrics |
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geneeskunde |
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medicine |
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volksgezondheid |
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public health |
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reumatiek |
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rheumatism |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
Vendor-supplied metadata |
| Subject |
Adrenocortical hormones -- Therapeutic use
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Adrenocortical hormones -- Effectiveness
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Pediatrics.
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Adrenocorticotropic Hormone -- therapeutic use
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Pediatrics
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MEDICAL -- Pharmacology.
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Adrenocortical hormones -- Therapeutic use
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Pediatrics
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| Form |
Electronic book
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| Author |
Cimaz, Rolando, editor.
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| ISBN |
9783319160566 |
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3319160567 |
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3319160559 |
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9783319160559 |
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