| Description |
1 online resource (417 p.) |
| Series |
Progress in molecular biology and translational science, 1877-1173 ; v. 94 |
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Progress in molecular biology and translational science ; v. 94.
|
| Contents |
Front Cover; Progress in Molecular Biology and Translational Science: Genes and Obesity; Copyright Page; Contents; Contributors; Preface; Chapter 1: Genetics and Genomics of Obesity: Current Status; I. Familial Risk Level and Heritability Coefficients; II. Scope of the Volume; References; Chapter 2: Genes and Pathways Contributing to Obesity: A Systems Biology View; I. Introduction; II. Systems Biology: A Brief Overview; III. Integrative Genetics as a ""Top-Down"" Systems Biology Approach; IV. Metabolic Networks as a ""Bottom-Up"" Systems Biology Approach |
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V. Other Areas of Relevance and Future DirectionVI. Conclusions; References; Chapter 3: Genetics of Adipose Tissue Biology; I. Human White Adipose Tissue in Health and Disease; II. Genetics of Fat Cell Lipid Storage and Mobilization; III. Genetics of WAT Endocrine Function; IV. Genetics of Fat Cell Morphology; V. Adipocyte Phenotypes of Established Susceptibility Genes for Obesity; VI. Caveats with Genetic Studies of Adipose Function; VII. Summary and Future Directions; References; Chapter 4: The Genetics of Brown Adipose Tissue; I. Introduction; II. Genetics of BAT in Mice |
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III. Genetic Variability in the Induction of Brown Fat and the Obese PhenotypeIV. Chromosomal Mapping of Genes Controlling Brown Fat Induction by QTL Analysis: Rationale and Strategy for a Genetic Analysis; V. Transcription Factors Controlling Ucp1 Expression and QTLs Associated with Brown Adipocyte Induction in Retroperitoneal Fat; VI. Transgressive Variation: A Manifestation of Synergistic Interactions Between QTLs and Between Transcription Factors and Signaling Molecules that Control Ucp 1 Expression; VII. The Development of a Brown Adipocyte Lineage |
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VIII. Transgenic Models to Explore the Role of Brown Fat in Thermogenesis and Body Weight RegulationIX. BAT in Humans; X. The Genetics of BAT and UCP1 in Humans; XI. Summary and Perspectives; Acknowledgments; References; Chapter 5: Obesity in Single Gene Disorders; I. Introduction; II. Nonsyndromic Obesity; III. Syndromic Obesity; IV. Copy Number Variants in Obesity; V. Closing Remarks; References; Chapter 6: A Translational View of the Genetics of Lipodystrophy and Ectopic Fat Deposition; I. Introduction; II. Components of a Thorough Investigation of a Suspected Lipodystrophy Case |
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III. Generalized LipodystrophiesIV. Lipodystrophies Affecting Selected Lipid Depots (Partial); V. Syndromes Including Lipodystrophy; VI. Overview of Molecular Pathways Affected in Lipodystrophy Syndromes; VII. Therapy for Lipodystrophy Patients; VIII. Uncovering Additional Responsible Genetic Variants; IX. Inherited Partial Lipodystrophies as a Model for Common Metabolic Syndrome (MetS); X. Conclusions; Acknowledgments; References; Chapter 7: Cutting the Fat: The GeneticDissection of Body Weight; I. Introduction; II. Strategies for Finding Genes Contributing to Obesity |
| Summary |
A number of genes have been identified that are associated with an increased body mass index (BMI), the standard measurement of obesity. By analyzing these genes, researchers hope to gain a better understanding of what causes obesity and develop ways to tackle the problem. The study of genes and obesity could lead to new treatments. This volume reviews the latest developments in the field. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involve |
| Main Series |
Progress in molecular biology and translational science |
| Notes |
Description based upon print version of record |
|
III. The State of Knowledge in the Genetics of Obesity |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Adipose tissues -- Metabolism
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Eating disorders -- Genetics
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Obesity -- Genetic aspects
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Obesity -- Genetic aspects
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| Form |
Electronic book
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| Author |
Bouchard, Claude
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| ISBN |
1282954504 |
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9781282954502 |
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9786612954504 |
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6612954507 |
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0080962033 |
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9780080962030 |
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