Cover; Half Title; Title Page; Copyright Page; Contents; Editors; Preface; Contributors; I: Phase I designs; 1 Overview of Phase I Designs; 2 Model-Based Designs for Safety; 3 Dose-Finding Methods for Nonbinary Outcomes; 4 Dose-Finding Trials in Pediatric Oncology; II: More advanced Phase I and Phase I/II methodology; 5 Phase I/II Dose-Finding Designs with Efficacy and Safety Endpoints; 6 Designing Early-Phase Drug Combination Trials; 7 Dose-Schedule Finding in Early-Phase Clinical Trials; 8 Patient Heterogeneity in Dose-Finding Trials
9 Nonparametric Optimal Design in Adaptive Dose-Finding Studies10 Practical Implementation: Protocol Development; III: Phase II Dose-Finding Trials; 11 Dose-Finding Studies in Phase II: Introduction and Overview; 12 The MCP-Mod Methodology: Practical Considerations and the DoseFinding R Package; 13 Designing Phase II Dose-Finding Studies: Sample Size, Doses, and Dose Allocation Weights; 14 Two-Stage Designs in Dose Finding; 15 Longitudinal Dose-Response Models; 16 Multiple Test Strategies for Comparing Several Doses with a Control in Confirmatory Trials
