Title Drug design : cutting edge approaches / edited by Darren R. Flower

Published Cambridge, UK : Royal Society of Chemistry, ©2002

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Description 1 online resource (x, 192 pages) : illustrations Series Special publication ; no. 279 Special publication (Royal Society of Chemistry (Great Britain)) ; no. 279. Contents Molecular informatics : sharpening drug design's cutting edge -- High-throughput X-ray crystallography for drug discovery -- Trawling the genome for G protein-coupled receptors : the importance of integrating bioinformatic approaches -- Virtual screening of virtual libraries : an efficient startegy for lead generation -- Virtual techniques for lead optimisation -- The impact of physical organic chemistry on the control of drug-like properties -- Mutagenesis and modelling highlight the critical nature of the TM2-loop-TM3 region of biogenic amine GPCRs -- Computational vaccine design Summary Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others Analysis drug design medicinal chemistry RSC BMCS MMG Notes "The proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--Title page verso Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL English Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Subject Drugs -- Design -- Congresses Drugs -- Design -- Mathematical models -- Congresses Artificial intelligence -- Medical applications -- Congresses Drugs -- Research -- Methodology -- Congresses Mathematical models. Pharmaceutical technology. Pharmaceutical chemistry. Pharmacology. Chemistry. Physical sciences. Life sciences. Drugs -- Design. Methodology. Chemical models. Molecular pharmacology -- Computer simulation Pharmacology, Experimental -- Computer simulation Computer simulation. Digital computer simulation. Drug Discovery Investigative Techniques Publication Formats Models, Theoretical Computing Methodologies Technology, Pharmaceutical Publication Characteristics Analytical, Diagnostic and Therapeutic Techniques and Equipment Chemistry, Pharmaceutical Information Science Pharmacology Chemistry Natural Science Disciplines Biological Science Disciplines Disciplines and Occupations Drug Design Combinatorial Chemistry Techniques Methods Congresses Models, Chemical Computer Simulation mathematical models. pharmacology. chemistry. physical sciences. biological sciences. methodology. simulation. Chemistry. MEDICAL -- Drug Guides. MEDICAL -- Nursing -- Pharmacology. MEDICAL -- Pharmacology. MEDICAL -- Pharmacy. Science. Physical sciences Pharmacology Pharmaceutical technology Pharmaceutical chemistry Methodology Mathematical models Life sciences Digital computer simulation Computer simulation Chemistry Chemical models Artificial intelligence -- Medical applications Drugs -- Design Drugs -- Research -- Methodology Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Flower, Darren R. LC no. 2006270060 ISBN 0854048162 9780854048168 9781847550705 1847550703 1601190271 9781601190277

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