A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS
Drug Resistance, Multiple, Bacterial -- prevention & control : Addressing the threat of drug-resistant tuberculosis : a realistic assessment of the challenge : workshop summary / Robert Giffin and Sally Robinson, rapporteurs ; Institute of Medicine of the National Academies
Drug Resistance -- South Africa -- Congresses : Emerging threat of drug-resistant tuberculosis in southern Africa : global and local challenges and solution : summary of a joint workshop / by the Institute of Medicine and the Academy of Science of South Africa ; Steve Olson, Yeonwoo Lebovitz, and Anne Claiborne, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board of Medicine, Institute of Medicine of the National Academies, and Academy of Science of South Africa
2011
1
Drug resistance -- Statistics : Anti-tuberculosis drug resistance in the world : fourth global report : the World Health Organization/International Union Against Tuberculosis and Lung Disease (WHO/UNION) Global Project on Anti-Tuberculosis Drug Resistance Surveillance, 2002-2007 / [written by Abigail Wright, Matteo Zignol]
2008
1
Drug resistance to microorganisms : Tolerance of Pseudomonas aeruginosa to tea tree oil : a report for the Rural Industries Research and Development Corporation / by C.F. Carson ... [and others]
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS)
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS
DRUG SEIZURES. : Precursors and chemicals frequently used in the illicit manufacture of narcotic drugs and psychotropic substances : report of the International Narcotics Control Board for 2004 on the implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals
