| Description |
1 online resource |
| Contents |
Part I. Introduction to Drug-Drug Interactions -- 1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions -- 2. Pharmacodynamic Interactions: Core Concepts -- 3. Pharmacokinetic Interactions: Core Concepts -- 4. A Brief Treatise On The Area Under The Curve -- Part II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters -- 5. CYP2D6: Where It All Began -- 6. CYP2E1: The Anesthesia Enzyme -- 7. CYP3A4: The Workhorse -- 8. CYP1A2: The Switch-hitter -- 9. CYP2B: 2B or Not 2B?- 10. CYP2C9: The Support Crew I -- 11. CYP2C19: The Support Crew II -- 12. UGTs: Conjugating Cousins -- 13. The Cytochrome P450 System In Disease States--A Brief Review -- PART III. Drug-Drug Interactions: Paradigms and Core Concepts -- 14. P-glycoprotein and OATP Transporters -- 15. The "Fatal" Forty -- 16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions -- 17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma -- 18. Pharmacogenomics -- 19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important -- 20. The Lawyers Can Read, Too: Case Presentations from the Courtroom -- Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents -- 21. Introduction -- 22. That Sums It Up -- 23. 1+1+1+1=? -- 24. A Delayed Surgeon Is A "Dismayed" Surgeon? -- 25. Relax, It's Only Gentamicin -- 26. Jaundice After Surgery -- 27. Everybody Clear? -- 28. The Hemodynamic Hole -- 29. Alpha-2 To The Rescue But Beware Bradycardia -- 30. Hot Stuff! -- Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents -- 31. Introduction -- 32. How to Successfully Occlude an Intravenous Line -- 33. A Curious Cause of Seizures -- 34. Magnesium Mama And The Mad Dad -- 35. Dexy's Midnight Spinal -- Part VI. Drug-Drug Interactions Involving Local Anesthetics -- 36. Introduction -- 37. Comfortably Numb -- 38. Naturally Occurring And Nasty -- 39. LOL-LOL: Little Old Lady--Lots of Lido -- 40. The Spinal Countdown -- 41. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I -- 42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II -- 43. A Perfect Storm? -- 44. Shake Rattle and Roll -- 45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult -- 46. Fatal Pain Relief -- 47. Lipid Lifesaver -- Part VII. Drug-Drug Interactions Involving Opioids -- 48. Introduction -- 49. No 'Subs'titute for Sobriety -- 50. A Needle And The Damage Done -- 51. Dad's Not Having Much Pain -- 52. Royal Flush -- 53. The Worry That's Always With Us: Afternoon Nap -- 54. The Bawling Baby -- 55. Sleeping Beauty -- 56. Codeine Can't Do It -- 57. A Shuddering Interaction -- 58. Double Indemnity -- 59. Breaking the Codeine -- 60. The Ultimate Ultram Primer I: My Mood Is Better, But Boy Do I Hurt! -- 61. The Ultimate Ultram Primer II: I "Haight" Narcotics But I Hate Seizures Worse -- 62. The Ultimate Ultram Primer III: Tremor-dol Trigger in Serotonin Syndrome -- 63. Too Much of A Good Thing -- Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications -- 64. Introduction -- 65. Pining For Pete In The Pain Clinic -- 66. You Do Not Look Well Today, Mon Ami -- 67. My Headache is Gone, But My Leg Now Hurts -- 68. Special 'K'ase -- 69. Not Manic About NSAIDs -- 70. Keep It Capped! -- 71. The ACE Is Not Always High -- 72. When The Smoke Clears, Relaxation Disappears -- 73. Befuddled by Aspirin -- 74. You Can't Trick Us! -- Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives -- 75. Introduction -- 76. The Worry That's Always With Us: Now I'm Depressed -- 77. The Worry That's Always With Us: Tragic But Not Rare -- 78. Lack of Sedation -- 79. A Cold Isn't Going to Slow Me Down -- 80. Her Patients Never Wake Up On Time -- 81. When Enough Is Now Too Much -- 82. The Distressed Daughter -- 83. Check Check and Double Check -- 84. Doggone It--The Case is Cancelled -- 85. Noct' Out -- 86. Predisposed to Doze -- 87. Synergistic Sedation -- Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents -- 88. Introduction -- 89. Blocked Again -- 90. Irreversibility Sux -- 91. Keep An "Ion" The Twitches -- 92. A Reversal of Misfortune -- 93. Stop Moving -- 94. There's Just Not Enough Roc In The World -- 95. Slow Sux I: A Lengthy Wake-Up Period After Electroconvulsive Therapy -- 96. Slow Sux II: I Remember Reviewing This For The Boards -- 97. Slow Sux III: Where Did the Twitches Go? -- 98. Weakened All Weekend -- 99. The Patient Who Could Not Raise Her Head -- 100. An Unexpected Wait -- 101. Diabolical Cough Syrup -- Part XI. Drug-Drug Interactions Involving Antibiotics and Antifungals -- 102. Introduction -- 103. Full Stop -- 104. Flummoxed by the FLOX -- 105. Tales of Terror -- 106. Too Low To Go -- 107. A Fungal Story -- 108. Rejection Protection Turned Kidney Killer -- 109. Can't Get Well -- 110. Linezolid (I): Be VREy Careful -- 111. Linezolid (II): Hyper and Hot -- 112. Not Sweet At All -- 113. Where Did All The Sugar Go? -- 114. Exposed! (Part 1) -- 115. Exposed! (Part 2) -- 116. Seizures on 5 West -- Part XII. Drug-Drug Interactions Involving Cardiovascular Medications -- 117. Introduction -- 118. Riding The Rollercoaster -- 119. A Pressing Need For Vasopressin! -- 120. Too Young To Die -- 121. A Widening Gyre -- 122. Misusing Mom's Meds -- 123. If the Patient Has No Renal Failure, Why is Her Potassium So High? -- 124. Prazosin and the PTSD Paratrooper -- 125. Nicardipine Notes -- 126. Hypotension Harry -- 127. Too Slow to Flow -- 128. Better Sleep But Slower Heart -- 129. Extreme Blood Pressure After Ephedrine: Should We Rule Out Pheochromocytoma? -- 130. Heart-Stopping Treatment -- 131. Induction Crashes: Are There Clues In the Ashes? -- 132. The Wakeup Call: 2AM Trauma -- 133. Falling Down -- 134. A Hidden Drug -- 135. I'm Listening, I'm Listening -- 136. Jump Start My Heart -- 137. The Statin Trilogy (I): 'Statin' From The Beginning -- 138. The Statin Trilogy (II): Tripped And Fell At The Train 'Statin' -- 139. The Statin Trilogy (III): Welcome To The United 'Statins' Of America -- 140. Be Still, My Beating Heart -- 141. The Nice Niece -- 142. Cyclo Killer: Qu'est-ce que c'est? -- 143. Blurry-Eyed With Rapid Heart Beats -- Part XIII. Drug-Drug Interactions Involving Coagulation Modifiers -- 144. Introduction -- 145. Seize the Day -- 146. The Third and Final Complication -- 147. An Interaction With the Furniture -- 148. Macrolide Mishap for Little Miss Muffett -- 149. From Asymptomatic to Symptomatic: a Cause of Nosebleed -- 150. The Consequences of Not Following A Cardiac Diet -- 151. Clopidogrel (I): Bagel Brunch -- 152. Clopidogrel (II): Conferring Over The Kung Pao -- Part XIV. Drug-Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy -- 153. Introduction -- 154. Beaned -- 155. Addisonian Adjustment -- 156. Tea Time -- 157. No Fits at Uffizi -- 158. Quit Steroids Quit Kidneys -- 159. The Fall Guy (I) -- 160. The Fall Guy (2) -- 161. The Topic of the Day -- 162. Bounce Back -- 163. Call The Cath Lab! -- 164. The Imatinib Inquiry: A Theoretical Case (For Now) -- 165. A HAART-Breaking Tale -- Part XV. Drug-Drug Interactions Involving Neuropsychiatric Drugs -- 166. Introduction -- 167. Phenytoin (I): Going Crazy! -- 168. Phenytoin (II): The Wrong Drug for the Schizophrenic -- 169. Dizzy and Depressed -- 170. The Funeral Is On Monday -- 171. This Antacid Is Making Me Sick! -- 172. Young at Heart -- 173. Shiver Yes, Die No -- 174. Clip and Dip -- 175. Blue Fog -- 176. Confiscated Contraceptives -- 177. Gotta Love Derm -- 178. Desperate for A Drink -- Part XVI. Drug-Drug Interactions Involving QT Prolonging DDIs -- 179. Introduction -- 180. Delusion At Heart -- 181 |
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At Long Last -- 182. Metha-don't! -- 183. Flash Fire -- 184. I Am Dizzy When I Stand Up -- Part XVII. Drug-Drug Interactions Involving Foods and Nutrition -- 185. Introduction -- 186. High Fat Diet (I): No Juice For The Ketotic Kid -- 187. Protein Huffing and Puffing -- 188. Salty Sam -- 189. A Peak Potassium Problem -- 190. Awake? -- 191. Tropical Punch Packing a Real Knockout -- 192. When The Fire Won't Go Out -- 193. Peppermint Patty -- 194. From Bleeding Gums to Green Thumbs- A True Story -- 195. Delicious but Malicious -- 196. I Just Can't Lick This Problem -- 197. Sommelier's Surprise -- 198. Dairy Carefully -- 199. Cold And Sick, Sick And Cold -- 200. TPN (I): A Review and Two Interactions -- 201. TPN (II): A Traumatic Case of Increased Metabolism -- 202. Skin and Bones -- 203. Enough to Make You Sick -- 204. Determined and Desperate to Diet -- Part XVIII. Drug-Drug Interactions Involving Spices and Supplements -- 205. Introduction -- 206. Caffeine Crash -- 207. Sad Sequelae -- 208. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Seizures -- 209. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Sugar -- 210. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Subdural -- 211. "Khat" Unawares -- 212. Pain on the Plane -- 213. Ca va, c'est Kava -- 214. Summertime and the Herbals are Hot -- 215. Garlic I: More Than Just Bad Breath -- 216. Garlic II: A Girl Named Allicin -- 217. "Danshen" the Night Away -- 218. Caught Yellow-Handed -- 219. St. John: Not Such A Saint -- 220. Hearing the News |
| Summary |
The occurrence of deleterious or even fatal drug-drug interactions (DDIs)in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable toanesthesiologists and surgeons, and PharmDs, as well as trainees in those specialties; intensive care staff, including physicians, physician assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
English |
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Electronic resource; title from digital title page (ebrary website, viewed May 17, 2016) |
| In |
Springer eBooks |
| Subject |
Drug interactions -- Case studies
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Drug interactions.
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Surgery.
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Drug Interactions
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General Surgery
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surgery (health care function)
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MEDICAL -- Pharmacology.
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Drug interactions
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| Genre/Form |
Case studies
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Case studies.
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Études de cas.
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| Form |
Electronic book
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| Author |
Marcucci, Catherine, editor.
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| ISBN |
9781461474951 |
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1461474957 |
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1461474949 |
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9781461474944 |
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